Rapid identification of marine microorganisms is critical in marine ecology, and Raman spectroscopy is a promising means to achieve this. Single cell Raman spectra contain the biochemical profile of a cell, which can be used to identify cell phenotyp...
Images of laser scattering patterns generated by bacteria in urine are promising resources for deep learning. However, floating bacteria in urine produce dynamic scattering patterns and require deep learning of spatial and temporal features. We hypot...
We report a new method for the rapid identification of pathogenic bacterial species at the single-cell level that combines laser tweezers Raman spectroscopy (LTRS) with deep learning (DL). LTRS can accurately measure single-cell Raman spectra (scRS) ...
Rapid and accurate identification of the mechanisms of action (MoAs) of antibacterial compounds remains a challenge for the development of antibacterial compounds. Computational inference methods for determining the MoAs of antibacterial compounds ha...
Atmospheric nitrogen fixation carried out by microorganisms has environmental and industrial importance, related to the increase of soil fertility and productivity. The present work proposes the development of a new high precision system that allows ...
The characterization of therapeutic phage genomes plays a crucial role in the success rate of phage therapies. There are three checkpoints that need to be examined for the selection of phage candidates, namely, the presence of temperate markers, anti...
Many pore-forming proteins originating from pathogenic bacteria are toxic against agricultural pests. They are the key ingredients in several pesticidal products for agricultural use, including transgenic crops. There is an urgent need to identify no...
In contrast to the well characterized mitotic machinery in eukaryotes it seems as if there is no universal mechanism organizing chromosome segregation in all bacteria. Apparently, some bacteria even use combinations of different segregation mechanism...
In nature, bacteria exhibit a limited repertoire of behaviors in response to environmental changes. Synthetic biology has now opened up the possibility of programming cells or unicellular organisms in order to enable them to perform certain tasks, wh...
Improvements in microscopy software and hardware have dramatically increased the pace of image acquisition, making analysis a major bottleneck in generating quantitative, single-cell data. Although tools for segmenting and tracking bacteria within ti...