AIMC Topic: beta-Lactams

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Prediction of β-lactamase and its class by Chou's pseudo-amino acid composition and support vector machine.

Journal of theoretical biology Oct 22, 2014
β-Lactam class of antibiotics is used as major therapeutic agent against a number of pathogenic microbes. The widespread and indiscriminate use of antibiotics to treat bacterial infection has prompted evolution of several evading mechanisms from the ...
beta-Lactams Support Vector Machine Anti-Infective Agents beta-Lactamases Sequence Analysis, Protein Protein Structure, Secondary Amino Acid Sequence
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β-lactam resistance: epidemiological trends, molecular drivers, and innovative control strategies in the post-pandemic era.

Clinical microbiology reviews Sep 11, 2025
SUMMARY () is a major human pathogen that can cause severe diseases such as meningitis and bacteremia. β-lactam antibiotics are the most essential antimicrobial agents for treating infections, but the resistance has become a significant challenge in...
Humans COVID-19 Anti-Bacterial Agents Pandemics beta-Lactam Resistance Streptococcus pneumoniae Pneumococcal Infections beta-Lactams
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Low Predictability of Readmissions and Death Using Machine Learning in Cirrhosis.

The American journal of gastroenterology Feb 1, 2021
INTRODUCTION: Readmission and death in cirrhosis are common, expensive, and difficult to predict. Our aim was to evaluate the abilities of multiple artificial intelligence (AI) techniques to predict clinical outcomes based on variables collected at a...
Gastrointestinal Hemorrhage Proton Pump Inhibitors Patient Readmission Paracentesis Mortality Hepatic Encephalopathy Infections End Stage Liver Disease Ascites Water-Electrolyte Imbalance Clinical Decision Rules Gastrointestinal Agents beta-Lactams Kidney Diseases Rifaximin Lactulose Adrenergic beta-Antagonists Hydrothorax Female Support Vector Machine Aged ROC Curve Reproducibility of Results Machine Learning Middle Aged Humans Liver Cirrhosis Male Cohort Studies Logistic Models Severity of Illness Index Anti-Bacterial Agents
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Systematic analysis of supervised machine learning as an effective approach to predicate β-lactam resistance phenotype in Streptococcus pneumoniae.

Briefings in bioinformatics Jul 15, 2020
Streptococcus pneumoniae is the most common human respiratory pathogen, and β-lactam antibiotics have been employed to treat infections caused by S. pneumoniae for decades. β-lactam resistance is steadily increasing in pneumococci and is mainly assoc...
Humans beta-Lactam Resistance Microbial Sensitivity Tests Supervised Machine Learning Streptococcus pneumoniae beta-Lactams
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