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Bradykinin B2 Receptor Antagonists

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Pharmacokinetics of single and repeat doses of icatibant.

Clinical pharmacology in drug development
PURPOSE: Icatibant is a bradykinin-2 receptor antagonist approved to treat acute hereditary angioedema attacks in adults. To-date, no thorough investigation of the clinical pharmacokinetic (PK) parameters of icatibant and its primary metabolites has ...