Archives of gynecology and obstetrics
Oct 23, 2017
OBJECTIVE: Breast cancer is a severe risk to public health and has adequately convoluted pathogenesis. Therefore, the description of key molecular markers and pathways is of much importance for clarifying the molecular mechanism of breast cancer-asso...
Glutamine (Gln), a critical metabolic substrate, fuels the uncontrolled proliferation of cancer cells. Cancer-associated fibroblasts (CAFs), essential components of the tumor microenvironment, facilitate tumor progression by supplying Gln to cancer c...
Solid cancers are complex "ecosystems" comprised of diverse cell types and extracellular molecules, in which heterotypic interactions significantly influence disease etiology and therapeutic response. However, our current understanding of tumor micro...
Interdisciplinary sciences, computational life sciences
Jun 1, 2025
Existing single-cell clustering methods are based on gene expressions that are susceptible to dropout events in single-cell RNA sequencing (scRNA-seq) data. To overcome this limitation, we proposed a pathway-based clustering method for single cells (...
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