AIMC Topic: Cell Plasticity

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Morphological profiling using machine learning reveals emergent subpopulations of interferon-γ-stimulated mesenchymal stromal cells that predict immunosuppression.

Cytotherapy Nov 28, 2018
BACKGROUND: Although a preponderance of pre-clinical data demonstrates the immunosuppressive potential of mesenchymal stromal cells (MSCs), significant heterogeneity and lack of critical quality attributes (CQAs) based on immunosuppressive capacity l...
Humans Machine Learning Cells, Cultured Leukocytes, Mononuclear Lymphocyte Activation Cell Proliferation CD8-Positive T-Lymphocytes Immunosuppression Therapy CD4-Positive T-Lymphocytes Mesenchymal Stem Cells Coculture Techniques Interferon-gamma Stochastic Processes Tissue Embedding Cell Plasticity
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Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm.

Cancer research Aug 1, 2025
UNLABELLED: Cancer drug resistance is multifactorial, driven by heritable (epi)genetic changes but also by phenotypic plasticity. In this study, we dissected the drivers of resistance by perturbing organoids derived from patients with colorectal canc...
Humans Phenotype Colorectal Neoplasms Genotype Epigenesis, Genetic Gene Expression Regulation, Neoplastic Clonal Evolution Drug Resistance, Neoplasm Cell Plasticity Organoids
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