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Clonal Evolution

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Novel approaches for glioblastoma treatment: Focus on tumor heterogeneity, treatment resistance, and computational tools.

Cancer reports (Hoboken, N.J.) 32729241
BACKGROUND: Glioblastoma (GBM) is a highly aggressive primary brain tumor. Currently, the suggested line of action is the surgical resection followed by radiotherapy and treatment with the adjuvant temozolomide, a DNA alkylating agent. However, the a...
Antineoplastic Combined Chemotherapy Protocols Brain Brain Neoplasms Cancer Vaccines Chemoradiotherapy, Adjuvant Clonal Evolution Computational Biology DNA Modification Methylases DNA Mutational Analysis DNA Repair Enzymes Drug Resistance, Neoplasm Genetic Heterogeneity Glioblastoma Humans Immune Checkpoint Inhibitors Machine Learning Microtubules Models, Genetic Mutation Precision Medicine Prognosis Tumor Microenvironment Tumor Suppressor Protein p53 Tumor Suppressor Proteins
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