AIMC Topic: Clonal Evolution

Clear Filters Showing 1 to 2 of 2 articles

Novel approaches for glioblastoma treatment: Focus on tumor heterogeneity, treatment resistance, and computational tools.

Cancer reports (Hoboken, N.J.) Nov 11, 2019
BACKGROUND: Glioblastoma (GBM) is a highly aggressive primary brain tumor. Currently, the suggested line of action is the surgical resection followed by radiotherapy and treatment with the adjuvant temozolomide, a DNA alkylating agent. However, the a...
Humans Machine Learning Brain Precision Medicine Prognosis Tumor Microenvironment Brain Neoplasms Immune Checkpoint Inhibitors Computational Biology Cancer Vaccines Models, Genetic Antineoplastic Combined Chemotherapy Protocols Glioblastoma Mutation Genetic Heterogeneity Chemoradiotherapy, Adjuvant Clonal Evolution DNA Modification Methylases DNA Mutational Analysis DNA Repair Enzymes Drug Resistance, Neoplasm Microtubules Tumor Suppressor Protein p53 Tumor Suppressor Proteins
View on PubMed DOI

Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm.

Cancer research Aug 1, 2025
UNLABELLED: Cancer drug resistance is multifactorial, driven by heritable (epi)genetic changes but also by phenotypic plasticity. In this study, we dissected the drivers of resistance by perturbing organoids derived from patients with colorectal canc...
Humans Phenotype Colorectal Neoplasms Genotype Epigenesis, Genetic Gene Expression Regulation, Neoplastic Clonal Evolution Drug Resistance, Neoplasm Cell Plasticity Organoids
View on PubMed DOI
Popular Topics
Recent Journals