AIMC Topic: Clonal Evolution

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Novel approaches for glioblastoma treatment: Focus on tumor heterogeneity, treatment resistance, and computational tools.

Cancer reports (Hoboken, N.J.) Nov 11, 2019
BACKGROUND: Glioblastoma (GBM) is a highly aggressive primary brain tumor. Currently, the suggested line of action is the surgical resection followed by radiotherapy and treatment with the adjuvant temozolomide, a DNA alkylating agent. However, the a...
Humans Machine Learning Brain Precision Medicine Prognosis Tumor Microenvironment Brain Neoplasms Immune Checkpoint Inhibitors Computational Biology Cancer Vaccines Models, Genetic Antineoplastic Combined Chemotherapy Protocols Glioblastoma Mutation Genetic Heterogeneity Chemoradiotherapy, Adjuvant Clonal Evolution DNA Modification Methylases DNA Mutational Analysis DNA Repair Enzymes Drug Resistance, Neoplasm Microtubules Tumor Suppressor Protein p53 Tumor Suppressor Proteins
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