The rapid increase of metabolomics has led to an increasing focus on metabolic pathway modeling and reconstruction. In particular, reconstructing an organism's metabolic network based on its genome sequence is a key challenge in systems biology. The ...
We propose a method, called bi-point input, for convolutional neural networks (CNNs) that handle variable-length input features (e.g., speech utterances). Feeding input features into a CNN in a mini-batch unit requires that all features in each mini-...
Journal of applied clinical medical physics
Jun 10, 2022
A large volume of medical data are labeled using nonstandardized nomenclature. Although efforts have been made by the American Association of Physicists in Medicine (AAPM) to standardize nomenclature through Task Group 263 (TG-263), there remain nonc...
INTRODUCTION: To continue closing the gap between the predictive modeling and its real-world application, we report a new data-to-prediction pipeline that advanced the state-of-the-art predictive performance of body mass index (BMI) classifications b...
Antibacterial drugs (AD) change the metabolic status of bacteria, contributing to bacterial death. However, antibiotic resistance and the emergence of multidrug-resistant bacteria increase interest in understanding metabolic network (MN) mutations an...
Nuclear magnetic resonance (NMR) spectroscopy is highly unbiased and reproducible, which provides us a powerful tool to analyze mixtures consisting of small molecules. However, the compound identification in NMR spectra of mixtures is highly challeng...
Physical and engineering sciences in medicine
May 30, 2022
Chest X-rays are arguably the de facto medical imaging technique for diagnosing thoracic abnormalities. Chest X-ray analysis is complex, especially in asymptomatic diseases, and relies heavily on the expertise of radiologists. This work proposes the ...
The ability to estimate the probability of a drug to receive approval in clinical trials provides natural advantages to optimizing pharmaceutical research workflows. Success rates of clinical trials have deep implications for costs, duration of devel...
Brazilian legal system prescribes means of ensuring the prompt processing of court cases, such as the principle of reasonable process duration, the principle of celerity, procedural economy, and due legal process, with a view to optimizing procedural...
INTRODUCTION: Coding medicinal products described on adverse event (AE) reports to specific entries in standardised drug dictionaries, such as WHODrug Global, is a time-consuming step in case processing activities despite its potential for automation...
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