Pakistan journal of pharmaceutical sciences
38264893
Iron oxide nanoparticles (FeO NPs) stabilized with Moringa oleifera (M.O.) were successfully synthesized. The study aimed to explore the cytotoxic, anti-proliferative and anti-microbial potential of FeO NPs through various assays, including trypan bl...
To achieve accurate detection of AFB1 toxin content in agricultural products and avoid false-positive rates in the assays, the specificity of mAbs is critical. We improved the specificity of the prepared monoclonal antibodies by modifying the traditi...
Journal of chemical information and modeling
38394344
As part of the ongoing quest to find or construct large data sets for use in validating new machine learning (ML) approaches for bioactivity prediction, it has become distressingly common for researchers to combine literature IC data generated using ...
BACKGROUND: The coronavirus disease-2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has urgently necessitated effective therapeutic solutions, with a focus on rapidly identifying and classifying poten...
Design-Make-Test-Analyse (DMTA) is the discovery cycle through which molecules are designed, synthesised, and assayed to produce data that in turn are analysed to inform the next iteration. The process is repeated until viable drug candidates are ide...
Computer models of the human ventricular cardiomyocyte action potential (AP) have reached a level of detail and maturity that has led to an increasing number of applications in the pharmaceutical sector. However, interfacing the models with experimen...
Many chemicals in food packaging can leach as complex mixtures to food, potentially including substances hazardous to consumer health. Detecting and identifying all of the leachable chemicals are impractical with current analytical instrumentation an...
High Throughput Screening is crucial in pharmaceutical companies for efficient testing in drug discovery and development. Our Vaccines Analytical Research and Development (V-AR&D) department extensively uses robotic liquid handlers in their High Thro...
Herbicide contamination of aquatic ecosystems poses a critical risk to biodiversity. Bioassays provide useful ecological insights on responses to herbicides; however, they require a model organism. Ulva australis is an ideal candidate for herbicide t...
Journal of pharmaceutical and biomedical analysis
40187127
An innovative, integrated strategy was developed for rapid and comprehensive quality assessment of Ligusticum chuanxiong Hort., the key raw material for Guanxinning tablets. This approach simultaneously evaluates both chemical composition and biologi...