AIMC Topic: Drug Compounding

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Advancing algorithmic drug product development: Recommendations for machine learning approaches in drug formulation.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Aug 9, 2023
Artificial intelligence is a rapidly expanding area of research, with the disruptive potential to transform traditional approaches in the pharmaceutical industry, from drug discovery and development to clinical practice. Machine learning, a subfield ...
Artificial Intelligence Reproducibility of Results Drug Compounding Machine Learning Computer Simulation
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Deep learning image analysis models pretrained on daily objects are useful for the preliminary characterization of particulate pharmaceutical samples.

Biotechnology and bioengineering Jul 12, 2023
Visible and subvisible particles are a quality attribute in sterile pharmaceutical samples. A common method for characterizing and quantifying pharmaceutical samples containing particulates is imaging many individual particles using high-throughput i...
Excipients Drug Compounding Chemistry, Pharmaceutical Deep Learning Particle Size
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Game-based learning as training to use a chemotherapy preparation robot.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners Jun 8, 2023
INTRODUCTION: In 2015, our university hospital pharmacy acquired the PharmaHelp robot system to automate part of its chemotherapy production. Complex technical use, downtime periods, and insufficient training caused a drop in motivation and dispariti...
Antineoplastic Agents Self Efficacy Humans Male Pharmacy Service, Hospital Education, Pharmacy Motivation Robotics Drug Compounding
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Application of unsupervised and supervised learning to a material attribute database of tablets produced at two different granulation scales.

International journal of pharmaceutics May 20, 2023
The purpose of this study is to demonstrate the usefulness of machine learning (ML) for analyzing a material attribute database from tablets produced at different granulation scales. High shear wet granulators (scale 30 g and 1000 g) were used and da...
Pressure Tensile Strength Technology, Pharmaceutical Surface Properties Drug Compounding Particle Size Tablets Supervised Machine Learning
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Evaluation of cancer drug infusion devices prior to the implementation of a compounding robot.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners May 18, 2023
INTRODUCTION: Compounding robots are increasingly being implemented in hospital pharmacies. In our hospital, the recent acquisition of a robot (RIVA, ARxIUM) for intravenous cancer drug compounding obliged us to replace the previously used infusion d...
Robotics Drug Compounding Antineoplastic Agents Occupational Exposure Humans Neoplasms
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Considering inelasticity in the real-time monitoring of particle size for twin-screw granulation via acoustic emissions.

International journal of pharmaceutics Apr 11, 2023
A recently developed process analytical technology (PAT) using artificial intelligence to form the framework of its model, combining frequency-domain acoustic emissions (AE) and elastic impact mechanics to accurately predict complex particle size dis...
Technology, Pharmaceutical Particle Size Artificial Intelligence Drug Compounding
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Evaluation of Robotic Systems on Cytotoxic Drug Preparation: A Systematic Review and Meta-Analysis.

Medicina (Kaunas, Lithuania) Feb 22, 2023
: With the increased prevalence of patients with cancer, the demand for preparing cytotoxic drugs was increased by health-system pharmacists. To reduce the workload and contamination of work areas in pharmacies, compounding robots preparing cytotoxic...
Humans Antineoplastic Agents Drug Compounding Robotics Robotic Surgical Procedures
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Soft robot-enabled controlled release of oral drug formulations.

Soft matter Feb 15, 2023
The creation of highly effective oral drug delivery systems (ODDSs) has long been the main objective of pharmaceutical research. Multidisciplinary efforts involving materials, electronics, control, and pharmaceutical sciences encourage the developmen...
Robotics Drug Compounding Delayed-Action Preparations
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An overview of the implementation of SeDeM and SSCD in various formulation developments.

International journal of pharmaceutics Feb 8, 2023
The Sediment Delivery Model explains experimental analysis and quantitative assessment of the powdered substance characterizing parameters, which offer pertinent data about the material's appropriateness for direct compression (DC) of tablet, which i...
Pressure Excipients Expert Systems Drug Compounding Powders Tablets
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Rapid simultaneous analysis of anti human immunodeficiency virus drugs in pharmaceutical formulation by smart spectrophotometry based on multivariate calibration and least squares support vector machine methods.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Dec 31, 2022
In this study, two chemometrics methods, including partial least squares regression (PLS) and least squares support vector machine (LS-SVM) were applied for the simultaneous determination of zidovudine (ZDV) and lamivudine (LMV) in synthetic mixtures...
Zidovudine HIV Drug Compounding Calibration Spectrophotometry Least-Squares Analysis Support Vector Machine Lamivudine
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