AIMC Topic: Drug Compounding

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Game-based learning as training to use a chemotherapy preparation robot.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners Jun 8, 2023
INTRODUCTION: In 2015, our university hospital pharmacy acquired the PharmaHelp robot system to automate part of its chemotherapy production. Complex technical use, downtime periods, and insufficient training caused a drop in motivation and dispariti...
Self Efficacy Robotics Male Antineoplastic Agents Pharmacy Service, Hospital Education, Pharmacy Motivation Drug Compounding Humans
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Application of unsupervised and supervised learning to a material attribute database of tablets produced at two different granulation scales.

International journal of pharmaceutics May 20, 2023
The purpose of this study is to demonstrate the usefulness of machine learning (ML) for analyzing a material attribute database from tablets produced at different granulation scales. High shear wet granulators (scale 30 g and 1000 g) were used and da...
Supervised Machine Learning Drug Compounding Particle Size Tablets Pressure Tensile Strength Technology, Pharmaceutical Surface Properties
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Evaluation of cancer drug infusion devices prior to the implementation of a compounding robot.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners May 18, 2023
INTRODUCTION: Compounding robots are increasingly being implemented in hospital pharmacies. In our hospital, the recent acquisition of a robot (RIVA, ARxIUM) for intravenous cancer drug compounding obliged us to replace the previously used infusion d...
Occupational Exposure Neoplasms Robotics Antineoplastic Agents Humans Drug Compounding
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Considering inelasticity in the real-time monitoring of particle size for twin-screw granulation via acoustic emissions.

International journal of pharmaceutics Apr 11, 2023
A recently developed process analytical technology (PAT) using artificial intelligence to form the framework of its model, combining frequency-domain acoustic emissions (AE) and elastic impact mechanics to accurately predict complex particle size dis...
Artificial Intelligence Particle Size Drug Compounding Technology, Pharmaceutical
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Evaluation of Robotic Systems on Cytotoxic Drug Preparation: A Systematic Review and Meta-Analysis.

Medicina (Kaunas, Lithuania) Feb 22, 2023
: With the increased prevalence of patients with cancer, the demand for preparing cytotoxic drugs was increased by health-system pharmacists. To reduce the workload and contamination of work areas in pharmacies, compounding robots preparing cytotoxic...
Robotic Surgical Procedures Antineoplastic Agents Humans Drug Compounding Robotics
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Soft robot-enabled controlled release of oral drug formulations.

Soft matter Feb 15, 2023
The creation of highly effective oral drug delivery systems (ODDSs) has long been the main objective of pharmaceutical research. Multidisciplinary efforts involving materials, electronics, control, and pharmaceutical sciences encourage the developmen...
Drug Compounding Delayed-Action Preparations Robotics
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An overview of the implementation of SeDeM and SSCD in various formulation developments.

International journal of pharmaceutics Feb 8, 2023
The Sediment Delivery Model explains experimental analysis and quantitative assessment of the powdered substance characterizing parameters, which offer pertinent data about the material's appropriateness for direct compression (DC) of tablet, which i...
Expert Systems Drug Compounding Pressure Excipients Tablets Powders
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Rapid simultaneous analysis of anti human immunodeficiency virus drugs in pharmaceutical formulation by smart spectrophotometry based on multivariate calibration and least squares support vector machine methods.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Dec 31, 2022
In this study, two chemometrics methods, including partial least squares regression (PLS) and least squares support vector machine (LS-SVM) were applied for the simultaneous determination of zidovudine (ZDV) and lamivudine (LMV) in synthetic mixtures...
Zidovudine Calibration Spectrophotometry Drug Compounding Lamivudine Support Vector Machine HIV Least-Squares Analysis
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Processability evaluation of multiparticulate units prepared by selective laser sintering using the SeDeM Expert System approach.

International journal of pharmaceutics Oct 26, 2022
3D printing in dosage forms fabrication is in the focus of researchers, however, the attempts in multiparticulate units (MPUs) preparation are scarce. The aim of this study was to fabricate different size MPUs by selective laser sintering (SLS), usin...
Drug Compounding Lasers Excipients Powders Tablets Expert Systems
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Evaluation of a Self-Supervised Machine Learning Method for Screening of Particulate Samples: A Case Study in Liquid Formulations.

Journal of pharmaceutical sciences Oct 12, 2022
Imaging is commonly used as a characterization method in the pharmaceuticals industry, including for quantifying subvisible particles in solid and liquid formulations. Extracting information beyond particle size, such as classifying morphological sub...
Supervised Machine Learning Drug Compounding Image Processing, Computer-Assisted Proteins Neural Networks, Computer
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