AIMC Topic: Embryonic Stem Cells

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Knowledge-Based Analysis for Detecting Key Signaling Events from Time-Series Phosphoproteomics Data.

PLoS computational biology Aug 7, 2015
Cell signaling underlies transcription/epigenetic control of a vast majority of cell-fate decisions. A key goal in cell signaling studies is to identify the set of kinases that underlie key signaling events. In a typical phosphoproteomics study, phos...
Humans Proteomics Proteome Signal Transduction Cell Line Databases, Protein Cell Differentiation Phosphoproteins Cell Communication Knowledge Bases Embryonic Stem Cells
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Computational assignment of cell-cycle stage from single-cell transcriptome data.

Methods (San Diego, Calif.) Jul 2, 2015
The transcriptome of single cells can reveal important information about cellular states and heterogeneity within populations of cells. Recently, single-cell RNA-sequencing has facilitated expression profiling of large numbers of single cells in para...
Humans Machine Learning Animals Gene Expression Profiling Transcriptome Cell Line, Tumor Single-Cell Analysis Mice Computational Biology Hepatocytes Cell Cycle Embryonic Stem Cells
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[Construction of a High-precision Chemical Prediction System Using Human ESCs].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Jan 1, 2018
　Toxicity prediction based on stem cells and tissue derived from stem cells plays a very important role in the fields of biomedicine and pharmacology. Here we report on qRT-PCR data obtained by exposing 20 compounds to human embryonic stem (ES) cells...
Humans Support Vector Machine Phenols Benzhydryl Compounds Quantitative Structure-Activity Relationship Toxicity Tests Carcinogens Embryonic Stem Cells Neurotoxins Permethrin
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Deep learning of the splicing (epi)genetic code reveals a novel candidate mechanism linking histone modifications to ESC fate decision.

Nucleic acids research Dec 1, 2017
Alternative splicing (AS) is a genetically and epigenetically regulated pre-mRNA processing to increase transcriptome and proteome diversity. Comprehensively decoding these regulatory mechanisms holds promise in getting deeper insights into a variety...
Humans Neural Networks, Computer Machine Learning Sequence Analysis, RNA Epigenesis, Genetic Cell Line Cell Differentiation High-Throughput Nucleotide Sequencing Tumor Suppressor Proteins Ubiquitin-Protein Ligases Cell Lineage Alternative Splicing Embryonic Stem Cells Histone Code
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