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Ethical Review

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Refining humane endpoints in mouse models of disease by systematic review and machine learning-based endpoint definition.

ALTEX
Ideally, humane endpoints allow for early termination of experiments by minimizing an animal's discomfort, distress and pain, while ensuring that scientific objectives are reached. Yet, lack of commonly agreed methodology and heterogeneity of cut-off...

Big Health Data Research and Group Harm: The Scope of IRB Review.

Ethics & human research
Much of precision medicine is driven by big health data research-the analysis of massive datasets representing the complex web of genetic, behavioral, environmental, and other factors that impact human well-being. There are some who point to the Comm...

Artificial intelligence and medical research databases: ethical review by data access committees.

BMC medical ethics
BACKGROUND: It has been argued that ethics review committees-e.g., Research Ethics Committees, Institutional Review Boards, etc.- have weaknesses in reviewing big data and artificial intelligence research. For instance, they may, due to the novelty o...

The Prospect of Artificial Intelligence-Supported Ethics Review.

Ethics & human research
The burden of research ethics review falls not just on researchers, but also on those who serve on research ethics committees (RECs). With the advent of automated text analysis and generative artificial intelligence (AI), it has recently become possi...