AIMC Topic: Gene Duplication
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Ab initio GO-based mining for non-tandem-duplicated functional clusters in three model plant diploid genomes.
PloS one
Jun 19, 2020
A functional Non-Tandem Duplicated Cluster (FNTDC) is a group of non-tandem-duplicated genes that are located closer than expected by mere chance and have a role in the same biological function. The identification of secondary-compounds-related FNTDC...
Phylogeny analysis from gene-order data with massive duplications.
BMC genomics
Oct 16, 2017
BACKGROUND: Gene order changes, under rearrangements, insertions, deletions and duplications, have been used as a new type of data source for phylogenetic reconstruction. Because these changes are rare compared to sequence mutations, they allow the i...
Applying Machine Learning to Classify the Origins of Gene Duplications.
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2023
Nearly all lineages of land plants have experienced at least one whole-genome duplication (WGD) in their history. The legacy of these ancient WGDs is still observable in the diploidized genomes of extant plants. Genes originating from WGD-paleologs-c...
Predictive Models of Genetic Redundancy in Arabidopsis thaliana.
Molecular biology and evolution
Jul 29, 2021
Genetic redundancy refers to a situation where an individual with a loss-of-function mutation in one gene (single mutant) does not show an apparent phenotype until one or more paralogs are also knocked out (double/higher-order mutant). Previous studi...
Learning Retention Mechanisms and Evolutionary Parameters of Duplicate Genes from Their Expression Data.
Molecular biology and evolution
Mar 9, 2021
Learning about the roles that duplicate genes play in the origins of novel phenotypes requires an understanding of how their functions evolve. A previous method for achieving this goal, CDROM, employs gene expression distances as proxies for function...
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