AIMC Topic: Genetic Risk Score

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Enhanced osteoporotic fracture prediction in postmenopausal women using Bayesian optimization of machine learning models with genetic risk score.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research May 2, 2024
This study aimed to enhance the fracture risk prediction accuracy in major osteoporotic fractures (MOFs) and hip fractures (HFs) by integrating genetic profiles, machine learning (ML) techniques, and Bayesian optimization. The genetic risk score (GRS...
Humans Machine Learning Female Aged Middle Aged Risk Assessment Genome-Wide Association Study Polymorphism, Single Nucleotide Bayes Theorem Postmenopause Osteoporotic Fractures Genetic Risk Score
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Epistatic Features and Machine Learning Improve Alzheimer's Disease Risk Prediction Over Polygenic Risk Scores.

Journal of Alzheimer's disease : JAD Jan 1, 2024
BACKGROUND: Polygenic risk scores (PRS) are linear combinations of genetic markers weighted by effect size that are commonly used to predict disease risk. For complex heritable diseases such as late-onset Alzheimer's disease (LOAD), PRS models fail t...
Humans Machine Learning Female Aged Male Genome-Wide Association Study Genetic Predisposition to Disease Polymorphism, Single Nucleotide Models, Genetic Alzheimer Disease Apolipoproteins E Epistasis, Genetic Multifactorial Inheritance Genetic Risk Score
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