AIMC Topic: Glucagon-Like Peptide-1 Receptor

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Machine learning designs new GCGR/GLP-1R dual agonists with enhanced biological potency.

Nature chemistry May 16, 2024
Several peptide dual agonists of the human glucagon receptor (GCGR) and the glucagon-like peptide-1 receptor (GLP-1R) are in development for the treatment of type 2 diabetes, obesity and their associated complications. Candidates must have high poten...
Humans Machine Learning Peptides Drug Design Hypoglycemic Agents Amino Acid Sequence Glucagon-Like Peptide-1 Receptor Receptors, Glucagon Glucagon-Like Peptide-1 Receptor Agonists
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Ligand-Receptor Interactions and Machine Learning in GCGR and GLP-1R Drug Discovery.

International journal of molecular sciences Apr 14, 2021
The large amount of data that has been collected so far for G protein-coupled receptors requires machine learning (ML) approaches to fully exploit its potential. Our previous ML model based on gradient boosting used for prediction of drug affinity an...
Machine Learning Drug Discovery Ligands Glucagon-Like Peptide-1 Receptor
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