AIMC Topic: Glycerophospholipids

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Comprehensive multi-omics analysis reveals the core role of glycerophospholipid metabolism in the influence of short-chain fatty acids on the development of sepsis.

Scientific reports Aug 9, 2025
Sepsis is a systemic inflammatory response syndrome caused by infection, which has a high morbidity and mortality. Short-chain fatty acids (SCFAs) have been proved to improve the outcome of sepsis by regulating immunity and metabolism, but its specif...
Humans Animals Male Gene Expression Profiling Transcriptome Sepsis Mice Multiomics Disease Models, Animal Mice, Inbred C57BL Metabolomics Mendelian Randomization Analysis Fatty Acids, Volatile Glycerophospholipids
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Explore key genes of Crohn's disease based on glycerophospholipid metabolism: A comprehensive analysis Utilizing Mendelian Randomization, Multi-Omics integration, Machine Learning, and SHAP methodology.

International immunopharmacology Aug 21, 2024
BACKGROUND AND AIMS: Crohn's disease (CD) is a chronic, complex inflammatory condition with increasing incidence and prevalence worldwide. However, the causes of CD remain incompletely understood. We identified CD-related metabolites, inflammatory fa...
Humans Machine Learning Genetic Predisposition to Disease Multiomics Mendelian Randomization Analysis Crohn Disease Glycerophospholipids
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