AIMC Topic: Hemagglutinin Glycoproteins, Influenza Virus

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Conservation region finding for influenza A viruses by machine learning methods of N-linked glycosylation sites and B-cell epitopes.

Mathematical biosciences Jun 17, 2019
Influenza type A, a serious infectious disease of the human respiratory tract, poses an enormous threat to human health worldwide. It leads to high mortality rates in poultry, pigs, and humans. The primary target identity regions for the human immune...
Humans Machine Learning Influenza A virus Glycosylation Databases, Protein Influenza, Human Neuraminidase Viral Proteins Conserved Sequence Epitopes, B-Lymphocyte Hemagglutinin Glycoproteins, Influenza Virus
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Broadly active intranasal influenza vaccine with a nanocomplex particulate adjuvant targeting mast cells and toll-like receptor 9.

Journal of controlled release : official journal of the Controlled Release Society Aug 10, 2025
Flumist is the only FDA-approved intranasal influenza vaccine. Although it has recently been approved for at-home use, it has significant limitations. These include reduced effectiveness in generating a protective immune response in patients with ext...
Humans Female Animals Mice Nanoparticles Mice, Inbred BALB C Mast Cells Adjuvants, Immunologic Influenza Vaccines Orthomyxoviridae Infections Administration, Intranasal Oligodeoxyribonucleotides Hemagglutinin Glycoproteins, Influenza Virus Toll-Like Receptor 9
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Examining the Influenza A Virus Sialic Acid Binding Preference Predictions of a Sequence-Based Convolutional Neural Network.

Influenza and other respiratory viruses Dec 1, 2024
BACKGROUND: Though receptor binding specificity is well established as a contributor to host tropism and spillover potential of influenza A viruses, determining receptor binding preference of a specific virus still requires expensive and time-consumi...
Humans Neural Networks, Computer Machine Learning Influenza A virus Protein Binding Amino Acid Sequence Influenza, Human Hemagglutinin Glycoproteins, Influenza Virus Receptors, Virus N-Acetylneuraminic Acid
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