AIMC Topic: Insulin-Like Growth Factor Binding Proteins

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IGFBP7 and CCT2 are novel lactylation-driven mediators of endothelial-to-mesenchymal transition in idiopathic pulmonary fibrosis.

Functional & integrative genomics Nov 20, 2025
Lactylation is a post-translational modification that can influence the onset and progression of various diseases.However, its role in Idiopathic Pulmonary Fibrosis (IPF) has not been systematically investigated. Single-cell sequencing and bulk RNA s...
Humans Female Male Middle Aged Idiopathic Pulmonary Fibrosis Protein Processing, Post-Translational Epithelial-Mesenchymal Transition Insulin-Like Growth Factor Binding Proteins
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Artificial Intelligence-Guided Identification of IGFBP7 as a Critical Indicator in Lactic Metabolism Determines Immunotherapy Response in Stomach Adenocarcinoma.

Journal of cellular and molecular medicine Jan 1, 2025
Due to considerable tumour heterogeneity, stomach adenocarcinoma (STAD) has a poor prognosis and varies in response to treatment, making it one of the main causes of cancer-related mortality globally. Recent data point to a significant role for metab...
Humans Artificial Intelligence Prognosis Stomach Neoplasms Biomarkers, Tumor Male Cell Line, Tumor Immunotherapy Gene Expression Regulation, Neoplastic Cell Proliferation Adenocarcinoma Cell Movement Lactic Acid Insulin-Like Growth Factor Binding Proteins
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