Intrahepatic cholangiocarcinoma (iCCA) is a highly malignant liver cancer with limited treatment options. Recent evidence implicates lactate metabolism as playing a crucial role in tumor progression, but its precise contribution in iCCA remains uncle...
Journal of cancer research and clinical oncology
Dec 16, 2025
BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is a major type of kidney cancer, making up about 80% of cases, with advanced stages showing low survival rates. Current treatments face challenges like toxicity and drug resistance. Studies indicat...
Although it is the most common subtype of lung cancer in clinical practice, lung adenocarcinoma (LUAD) was proven to be associated with a poor prognosis. In recent years, lactate metabolism has been considered an important biological mechanism in lun...
Developing poly(lactic-co-glycolic) acid (PLGA) nanoparticles with optimized drug encapsulation and loading is crucial for effective drug delivery. However, controlling the physicochemical properties of these nanoparticles remains challenging. In thi...
BACKGROUND: Dengue shock syndrome (DSS), with critical complications encompassing mechanical ventilation (MV), dengue-associated acute liver failure (PALF), and encephalitis, is associated with high mortality in children. Although serum lactate is a ...
Severe COVID-19 often progresses to critical illness, requiring accurate prognostic biomarkers. Lactate-to-albumin ratio (LAR) has been proposed as a novel indicator to estimate the likelihood of death. Using data from the MIMIC database, this retros...
Analytical methods : advancing methods and applications
Oct 9, 2025
Non-invasive monitoring of lactate levels offers a promising avenue for optimizing athletic performance assessment, yet remains constrained by the limitations of traditional blood-based sampling methods. This review critically examines electrochemica...
Motivation drives individuals to overcome costs to achieve desired outcomes, such as rewards or avoidance of punishment, with significant variability across individuals. The dorsomedial prefrontal cortex/dorsal anterior cingulate cortex (dmPFC/dACC) ...
The detection of sweat metabolites is crucial for health monitoring, disease screening, and personalized medicine. Traditional methods encounter challenges like low metabolite concentrations, complex biological matrices, and difficulty in achieving m...
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