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Knowledge Bases

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Challenges in the construction of knowledge bases for human microbiome-disease associations.

Microbiome
The last few years have seen tremendous growth in human microbiome research, with a particular focus on the links to both mental and physical health and disease. Medical and experimental settings provide initial sources of information about these lin...

EK-DRD: A Comprehensive Database for Drug Repositioning Inspired by Experimental Knowledge.

Journal of chemical information and modeling
Drug repositioning, or the identification of new indications for approved therapeutic drugs, has gained substantial traction with both academics and pharmaceutical companies because it reduces the cost and duration of the drug development pipeline an...

A comprehensive knowledge base of synaptic electrophysiology in the rodent hippocampal formation.

Hippocampus
The cellular and synaptic architecture of the rodent hippocampus has been described in thousands of peer-reviewed publications. However, no human- or machine-readable public catalog of synaptic electrophysiology data exists for this or any other neur...

Mapping anatomical related entities to human body parts based on wikipedia in discharge summaries.

BMC bioinformatics
*: Background Consisting of dictated free-text documents such as discharge summaries, medical narratives are widely used in medical natural language processing. Relationships between anatomical entities and human body parts are crucial for building m...

Artificial Intelligence in Clinical Decision Support: a Focused Literature Survey.

Yearbook of medical informatics
OBJECTIVES: This survey analyses the latest literature contributions to clinical decision support systems (DSSs) on a two-year period (2017-2018), focusing on the approaches that adopt Artificial Intelligence (AI) techniques in a broad sense. The goa...

Quantitative identification of technological paradigm changes using knowledge persistence.

PloS one
This paper proposes a method to quantitatively identify the changes of technological paradigm over time. Specifically, the method identifies previous paradigms and predicts future paradigms by analyzing a patent citation-based knowledge network. The ...

Advances in gene ontology utilization improve statistical power of annotation enrichment.

PloS one
Gene-annotation enrichment is a common method for utilizing ontology-based annotations in gene and gene-product centric knowledgebases. Effective utilization of these annotations requires inferring semantic linkages by tracing paths through edges in ...

SinoPedia-A Linked Data Services platform for decentralized knowledge base.

PloS one
Knowledge bases are largely developed and utilized in academic and industrial fields, such as DBPedia, VIAF, LoC, Getty, and which are published in the Linked Data format. However, if you want to view different resources on these knowledge bases, you...

A subgraph-representation-based method for answering complex questions over knowledge bases.

Neural networks : the official journal of the International Neural Network Society
Knowledge-based question answering has attracted a lot of attention in the research communities of natural language processing and information retrieval. However, existing studies do not adequately address the problem of answering complex questions w...

Automated 4π radiotherapy treatment planning with evolving knowledge-base.

Medical physics
PURPOSE: Non-coplanar 4π radiotherapy generalizes intensity modulated radiation therapy (IMRT) to automate beam geometry selection but requires complicated hyperparameter tuning to attain superior plan quality, which can be tedious and inconsistent. ...