AIMC Topic: Knowledge Bases

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Automatic classification of lung nodule candidates based on a novel 3D convolution network and knowledge transferred from a 2D network.

Medical physics Nov 6, 2019
OBJECTIVE: In the automatic lung nodule detection system, the authenticity of a large number of nodule candidates needs to be judged, which is a classification task. However, the variable shapes and sizes of the lung nodules have posed a great challe...
Neural Networks, Computer Knowledge Bases Automation Image Processing, Computer-Assisted Tomography, X-Ray Computed Lung Neoplasms Sensitivity and Specificity
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The Clinical Pharmacogenetics Implementation Consortium: 10 Years Later.

Clinical pharmacology and therapeutics Nov 5, 2019
In 2009, the Clinical Pharmacogenetics Implementation Consortium (CPIC, www.cpicpgx.org), a shared project between Pharmacogenomics Knowledge Base (PharmGKB, http://www.pharmgkb.org) and the National Institutes of Health (NIH), was created to provide...
Knowledge Bases Humans Practice Guidelines as Topic Electronic Health Records Databases, Factual Pharmacogenetics
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Challenges in the annotation of pseudoenzymes in databases: the UniProtKB approach.

The FEBS journal Nov 3, 2019
The universal protein knowledgebase (UniProtKB) collects and centralises functional information on proteins across a wide range of species. In addition to the functional information added to all protein entries, for enzymes, which represent 20-40% of...
Humans Knowledge Bases Enzymes Databases, Protein
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Improving neural protein-protein interaction extraction with knowledge selection.

Computational biology and chemistry Oct 23, 2019
Protein-protein interaction (PPI) extraction from published scientific literature provides additional support for precision medicine efforts. Meanwhile, knowledge bases (KBs) contain huge amounts of structured information of protein entities and thei...
Models, Molecular Knowledge Bases Datasets as Topic Protein Interaction Mapping Proteins
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Molecular expression profiles of morphologically defined hippocampal neuron types: Empirical evidence and relational inferences.

Hippocampus Oct 9, 2019
Gene and protein expressions are key determinants of cellular function. Neurons are the building blocks of brain circuits, yet the relationship between their molecular identity and the spatial distribution of their dendritic inputs and axonal outputs...
Neurons Knowledge Bases Humans Transcriptome Empirical Research Data Mining Hippocampus
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Challenges in the construction of knowledge bases for human microbiome-disease associations.

Microbiome Sep 5, 2019
The last few years have seen tremendous growth in human microbiome research, with a particular focus on the links to both mental and physical health and disease. Medical and experimental settings provide initial sources of information about these lin...
Humans Natural Language Processing Microbiota Knowledge Bases Data Mining
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EK-DRD: A Comprehensive Database for Drug Repositioning Inspired by Experimental Knowledge.

Journal of chemical information and modeling Sep 3, 2019
Drug repositioning, or the identification of new indications for approved therapeutic drugs, has gained substantial traction with both academics and pharmaceutical companies because it reduces the cost and duration of the drug development pipeline an...
Animals Drug Repositioning Databases, Pharmaceutical Data Mining Knowledge Bases Small Molecule Libraries Drug Design Humans Software
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A comprehensive knowledge base of synaptic electrophysiology in the rodent hippocampal formation.

Hippocampus Aug 31, 2019
The cellular and synaptic architecture of the rodent hippocampus has been described in thousands of peer-reviewed publications. However, no human- or machine-readable public catalog of synaptic electrophysiology data exists for this or any other neur...
Knowledge Bases Electrophysiological Phenomena Data Mining Rodentia Synapses Age Factors Hippocampus Neuronal Plasticity Animals Male
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Mapping anatomical related entities to human body parts based on wikipedia in discharge summaries.

BMC bioinformatics Aug 17, 2019
*: Background Consisting of dictated free-text documents such as discharge summaries, medical narratives are widely used in medical natural language processing. Relationships between anatomical entities and human body parts are crucial for building m...
Anatomy Humans Algorithms Data Mining Patient Discharge Human Body Knowledge Bases
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Artificial Intelligence in Clinical Decision Support: a Focused Literature Survey.

Yearbook of medical informatics Aug 16, 2019
OBJECTIVES: This survey analyses the latest literature contributions to clinical decision support systems (DSSs) on a two-year period (2017-2018), focusing on the approaches that adopt Artificial Intelligence (AI) techniques in a broad sense. The goa...
Decision Support Systems, Clinical Knowledge Bases Bibliometrics Artificial Intelligence
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