Nucleic acids research
Jan 5, 2024
Emerging CRISPR-Cas9 technology permits synthetic lethality (SL) screening of large number of gene pairs from gene combination double knockout (CDKO) experiments. However, the poor integration and annotation of CDKO SL data in current SL databases li...
Nucleic acids research
Jan 5, 2024
Human endogenous retroviruses (HERVs), as remnants of ancient exogenous retrovirus infected and integrated into germ cells, comprise ∼8% of the human genome. These HERVs have been implicated in numerous diseases, and extensive research has been condu...
Nucleic acids research
Jan 5, 2024
Allosteric regulation, induced by perturbations at an allosteric site topographically distinct from the orthosteric site, is one of the most direct and efficient ways to fine-tune macromolecular function. The Allosteric Database (ASD; accessible onli...
Nucleic acids research
Jan 5, 2024
Aging entails gradual functional decline influenced by interconnected factors. Multiple hallmarks proposed as common and conserved underlying denominators of aging on the molecular, cellular and systemic levels across multiple species. Thus, understa...
Nucleic acids research
Jan 5, 2024
Biomarkers play an important role in various area such as personalized medicine, drug development, clinical care, and molecule breeding. However, existing animals' biomarker resources predominantly focus on human diseases, leaving a significant gap i...
AMIA ... Annual Symposium proceedings. AMIA Symposium
Jan 1, 2024
Healthcare providers learn continuously, but better support for provider learning is needed as new biomedical knowledge is produced at an increasing rate alongside widespread use of EHR data for clinical performance measurement. Precision feedback is...
AMIA ... Annual Symposium proceedings. AMIA Symposium
Jan 1, 2024
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AMIA ... Annual Symposium proceedings. AMIA Symposium
Jan 1, 2024
Large Language Models (LLMs), although powerful in general domains, often perform poorly on domain-specific tasks such as medical question answering (QA). In addition, LLMs tend to function as "black-boxes", making it challenging to modify their beha...
AMIA ... Annual Symposium proceedings. AMIA Symposium
Jan 1, 2024
We introduce an innovative automated system for the search and assessment of genetic variant evidence, meticulously aligned with ACMG guidelines. Leveraging the synergistic power of artificial intelligence (AI), elastic search, and an extensive knowl...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2024
Modeling and simulation (M&S), including in silico (clinical) trials, helps accelerate drug research and development and reduce costs and have coined the term "model-informed drug development (MIDD)." Data-driven, inferential approaches are now becom...