AIMC Topic: Knowledge Bases
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In Silico Clinical Trials: Is It Possible?
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2024
Modeling and simulation (M&S), including in silico (clinical) trials, helps accelerate drug research and development and reduce costs and have coined the term "model-informed drug development (MIDD)." Data-driven, inferential approaches are now becom...
HTNpedia: A Knowledge Base for Hypertension Research.
Combinatorial chemistry & high throughput screening
Jan 1, 2024
BACKGROUND: Hypertension is notably a serious public health concern due to its high prevalence and strong association with cardiovascular disease and renal failure. It is reported to be the fourth leading disease that leads to death worldwide.
LeafAI: query generator for clinical cohort discovery rivaling a human programmer.
Journal of the American Medical Informatics Association : JAMIA
Nov 17, 2023
OBJECTIVE: Identifying study-eligible patients within clinical databases is a critical step in clinical research. However, accurate query design typically requires extensive technical and biomedical expertise. We sought to create a system capable of ...
A multi-scale expression and regulation knowledge base for Escherichia coli.
Nucleic acids research
Oct 27, 2023
Transcriptomic data is accumulating rapidly; thus, scalable methods for extracting knowledge from this data are critical. Here, we assembled a top-down expression and regulation knowledge base for Escherichia coli. The expression component is a 1035-...
ActivePPI: quantifying protein-protein interaction network activity with Markov random fields.
Bioinformatics (Oxford, England)
Sep 2, 2023
MOTIVATION: Protein-protein interactions (PPI) are crucial components of the biomolecular networks that enable cells to function. Biological experiments have identified a large number of PPI, and these interactions are stored in knowledge bases. Howe...
Achieving pan-microbiome biological insights via the dbBact knowledge base.
Nucleic acids research
Jul 21, 2023
16S rRNA amplicon sequencing provides a relatively inexpensive culture-independent method for studying microbial communities. Although thousands of such studies have examined diverse habitats, it is difficult for researchers to use this vast trove of...
HAKE: A Knowledge Engine Foundation for Human Activity Understanding.
IEEE transactions on pattern analysis and machine intelligence
Jul 1, 2023
Human activity understanding is of widespread interest in artificial intelligence and spans diverse applications like health care and behavior analysis. Although there have been advances with deep learning, it remains challenging. The object recognit...
Microbiological and Virological Knowledge-Based Alert Service.
Studies in health technology and informatics
Jun 29, 2023
Hospital wards need immediate information about multi-resistant pathogens and contagious viruses in their hospitalized patients. An alert service configurable with Arden-Syntax-based alert definitions passing through an ontology service to complement...
Ethical Perspectives on Implementing AI to Predict Mortality Risk in Emergency Department Patients: A Qualitative Study.
Studies in health technology and informatics
May 18, 2023
Artificial intelligence (AI) is predicted to improve health care, increase efficiency and save time and recourses, especially in the context of emergency care where many critical decisions are made. Research shows the urgent need to develop principle...
Searching and Navigating UniProt Databases.
Current protocols
Mar 1, 2023
The Universal Protein Resource (UniProt) is a comprehensive resource for protein sequence and annotation data. The UniProt website receives about 800,000 unique visitors per month and is the primary means to access UniProt. It provides 10 searchable ...
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