AIMC Topic: Pseudomonas Infections

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Combinatorial discovery of microtopographical landscapes that resist biofilm formation through quorum sensing mediated autolubrication.

Nature communications
Bio-instructive materials that intrinsically inhibit biofilm formation have significant anti-biofouling potential in industrial and healthcare settings. Since bacterial surface attachment is sensitive to surface topography, we experimentally surveyed...

Predicting carbapenem-resistant Pseudomonas aeruginosa infection risk using XGBoost model and explainability.

Scientific reports
The prevalence and spread of carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a global public health problem. This study aims to identify the risk factors of CRPA infection and construct a machine learning model to provide a prediction tool for ...

Predicting drug resistance using artificial intelligence and clinical MALDI-TOF mass spectra.

mSystems
Matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) is widely used in clinical microbiology laboratories for bacterial identification but its use for detection of antimicrobial resistance (AMR) remains limited....

Rapid Discrimination of ST175 Isolates Involved in a Nosocomial Outbreak Using MALDI-TOF Mass Spectrometry and FTIR Spectroscopy Coupled with Machine Learning.

Transboundary and emerging diseases
The goal of this study was to evaluate matrix-assisted laser desorption ionization-iime of flight mass spectrometry (MALDI-TOF MS) and Fourier-transform infrared spectroscopy (FTIR-S) as diagnostic alternatives to DNA-based methods for the detection ...

A Genome-Based Model to Predict the Virulence of Pseudomonas aeruginosa Isolates.

mBio
Variation in the genome of , an important pathogen, can have dramatic impacts on the bacterium's ability to cause disease. We therefore asked whether it was possible to predict the virulence of isolates based on their genomic content. We applied a m...

DEEPred: Automated Protein Function Prediction with Multi-task Feed-forward Deep Neural Networks.

Scientific reports
Automated protein function prediction is critical for the annotation of uncharacterized protein sequences, where accurate prediction methods are still required. Recently, deep learning based methods have outperformed conventional algorithms in comput...

Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients.

International journal of antimicrobial agents
Dosing recommendations for continuous infusion of piperacillin, a broad-spectrum beta-lactam antibiotic, are mainly guided by outputs from population pharmacokinetic models constructed with intermittent infusion data. However, the probability of targ...

Application of the multifactor dimensionality reduction method in evaluation of the roles of multiple genes/enzymes in multidrug-resistant acquisition in Pseudomonas aeruginosa strains.

Epidemiology and infection
Multidrug-resistant Pseudomonas aeruginosa (MDRPA) infections are major threats to healthcare-associated infection control and the intrinsic molecular mechanisms of MDRPA are also unclear. We examined 348 isolates of P. aeruginosa, including 188 MDRP...