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Lysine

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l-Carnosine supplementation attenuated fasting glucose, triglycerides, advanced glycation end products, and tumor necrosis factor-α levels in patients with type 2 diabetes: a double-blind placebo-controlled randomized clinical trial.

Nutrition research (New York, N.Y.) 29420997
Considering the pathologic importance of metabolic disturbances, advanced glycation end products (AGEs), and chronic inflammation in diabetes mellitus and ameliorating potentials of l-carnosine in hampering these detritions and because these effects ...
Adipose Tissue Adult Arginine Blood Glucose Body Composition Carnosine Diabetes Mellitus, Type 2 Dietary Supplements Double-Blind Method Fasting Female Glycated Hemoglobin Glycation End Products, Advanced Humans Lysine Male Middle Aged Triglycerides Tumor Necrosis Factor-alpha
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New insights into the efficiency of thymol synergistic effect with p-cymene in inhibiting advanced glycation end products: A multi-way analysis based on spectroscopic and electrochemical methods in combination with molecular docking study.

Journal of pharmaceutical and biomedical analysis 29291586
Protein glycation in the body is one of the main reasons of diabetes complications. The electrochemical studies on the inhibitory mechanism of glycation are rather scarce. Thus, it is important to investigate the role of electrochemistry in the glyca...
Arginine Binding Sites Cymenes Drug Synergism Electrochemical Techniques Glycation End Products, Advanced Glycosylation Hypoglycemic Agents Kinetics Lysine Molecular Docking Simulation Monoterpenes Protein Binding Protein Conformation Protein Processing, Post-Translational Serum Albumin, Bovine Spectrophotometry, Ultraviolet Structure-Activity Relationship Thymol
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The Major Chromophore Arising from Glucose Degradation and Oxidative Stress Occurrence during Lens Proteins Glycation Induced by Glucose.

Molecules (Basel, Switzerland) 29271874
Glucose autoxidation has been proposed as a key reaction associated with deleterious effects induced by hyperglycemia in the eye lens. Little is known about chromophores generated during glucose autoxidation. In this study, we analyzed the effect of ...
Animals Cations, Divalent Cattle Copper Crystallins Gluconates Glucose Glycosylation Glyoxal Hydrogen Peroxide Lens, Crystalline Lysine Oxidation-Reduction Oxidative Stress Pyruvaldehyde Solutions
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Positive-Unlabeled Learning for Pupylation Sites Prediction.

BioMed research international 27579315
Pupylation plays a key role in regulating various protein functions as a crucial posttranslational modification of prokaryotes. In order to understand the molecular mechanism of pupylation, it is important to identify pupylation substrates and sites ...
Algorithms Binding Sites Databases, Protein Lysine Machine Learning Protein Processing, Post-Translational Proteins Support Vector Machine Ubiquitination
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Identify and analysis crotonylation sites in histone by using support vector machines.

Artificial intelligence in medicine 28283358
OBJECTIVE: Lysine crotonylation (Kcr) is a newly discovered histone posttranslational modification, which is specifically enriched at active gene promoters and potential enhancers in mammalian cell genomes. Although lysine crotonylation sites can be ...
Amino Acid Sequence Animals Computational Biology Databases, Protein Histones Humans Lysine Mice Protein Processing, Post-Translational Reproducibility of Results Support Vector Machine
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Prediction of lysine propionylation sites using biased SVM and incorporating four different sequence features into Chou's PseAAC.

Journal of molecular graphics & modelling 28763688
Lysine propionylation is an important and common protein acylation modification in both prokaryotes and eukaryotes. To better understand the molecular mechanism of propionylation, it is important to identify propionylated substrates and their corresp...
Acetylation Algorithms Amino Acid Sequence Amino Acids Computational Biology Lysine Peptides Position-Specific Scoring Matrices Protein Processing, Post-Translational Reproducibility of Results Support Vector Machine
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Predicting lysine glycation sites using bi-profile bayes feature extraction.

Computational biology and chemistry 29040908
Glycation is a nonenzymatic post-translational modification which has been found to be involved in various biological processes and closely associated with many metabolic diseases. The accurate identification of glycation sites is important to unders...
Bayes Theorem Computational Biology Glycosylation Internet Lysine Support Vector Machine
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Glypre: In Silico Prediction of Protein Glycation Sites by Fusing Multiple Features and Support Vector Machine.

Molecules (Basel, Switzerland) 29099805
Glycation is a non-enzymatic process occurring inside or outside the host body by attaching a sugar molecule to a protein or lipid molecule. It is an important form of post-translational modification (PTM), which impairs the function and changes the ...
Algorithms Amino Acids Area Under Curve Binding Sites Computer Simulation Glycosylation Lysine Proteins ROC Curve Sensitivity and Specificity Support Vector Machine
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Prediction of lysine glutarylation sites by maximum relevance minimum redundancy feature selection.

Analytical biochemistry 29641975
Lysine glutarylation is new type of protein acylation modification in both prokaryotes and eukaryotes. To better understand the molecular mechanism of glutarylation, it is important to identify glutarylated substrates and their corresponding glutaryl...
Acylation Glutarates Lysine Protein Processing, Post-Translational Proteins Sequence Analysis, Protein Software Support Vector Machine
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Predicting lysine-malonylation sites of proteins using sequence and predicted structural features.

Journal of computational chemistry 29761520
Malonylation is a recently discovered post-translational modification (PTM) in which a malonyl group attaches to a lysine (K) amino acid residue of a protein. In this work, a novel machine learning model, SPRINT-Mal, is developed to predict malonylat...
Animals Bacterial Proteins Hominidae Humans Lysine Machine Learning Malonates Mice Molecular Structure Protein Processing, Post-Translational Saccharopolyspora
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