IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
MicroRNAs (miRNAs) play a significant role in cell differentiation, biological development as well as the occurrence and growth of diseases. Although many computational methods contribute to predicting the association between miRNAs and diseases, the...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Currently, biomedical event extraction has received considerable attention in various fields, including natural language processing, bioinformatics, and computational biomedicine. This has led to the emergence of numerous machine learning and deep le...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Generating high-quality and drug-like molecules from scratch within the expansive chemical space presents a significant challenge in the field of drug discovery. In prior research, value-based reinforcement learning algorithms have been employed to g...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Precisely predicting Drug-Drug Interactions (DDIs) carries the potential to elevate the quality and safety of drug therapies, protecting the well-being of patients, and providing essential guidance and decision support at every stage of the drug deve...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
In this paper, we propose a Learning-based gEnome Codec (LEC), which is designed for high efficiency and enhanced flexibility. The LEC integrates several advanced technologies, including Group of Bases (GoB) compression, multi-stride coding and bidir...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Piwi-interacting RNAs (piRNAs) are increasingly recognized as potential biomarkers for various diseases. Investig-ating the complex relationship between piRNAs and diseases through computational methods can reduce the costs and risks associated with ...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Hypothesis Generation (HG) aims to expedite biomedical researches by generating novel hypotheses from existing scientific literature. Most existing studies focused on modeling static snapshots of the corpus, neglecting the temporal evolution of scien...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
The function labeling of enzymes has a wide range of application value in the medical field, industrial biology and other fields. Scientists define enzyme categories by enzyme commission (EC) numbers. At present, although there are some tools for enz...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Increasing evidence has indicated that RNA-binding proteins (RBPs) play an essential role in mediating alternative splicing (AS) events during epithelial-mesenchymal transition (EMT). However, due to the substantial cost and complexity of biological ...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 10, 2024
Tuberculosis has plagued mankind since ancient times, and the struggle between humans and tuberculosis continues. Mycobacterium tuberculosis is the leading cause of tuberculosis, infecting nearly one-third of the world's population. The rise of pepti...