AIMC Topic: Piwi-Interacting RNA

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rbpTransformer: A novel deep learning model for prediction of piRNA and mRNA bindings.

PloS one Jun 25, 2025
An important issue in biotechnology is predicting whether a piRNA and an mRNA will or will not bind. Research and treatment of diseases, drug discovery, and the silencing and regulation of genes, transposons, and genomic stability may all benefit fro...
Algorithms RNA, Small Interfering Piwi-Interacting RNA Deep Learning RNA, Messenger Humans Computational Biology
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Machine-learning diagnostics of breast cancer using piRNA biomarkers.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals Mar 4, 2025
BACKGROUND AND OBJECTIVES: Prior studies have shown that small non-coding RNAs (sncRNAs) are associated with cancer occurrence or development. Recently, a newly discovered class of small ncRNAs known as PIWI-interacting RNAs (piRNAs) have been found ...
Breast Neoplasms Biomarkers, Tumor Female Piwi-Interacting RNA RNA, Small Interfering Logistic Models Machine Learning Humans
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Mammalian piRNA target prediction using a hierarchical attention model.

BMC bioinformatics Feb 11, 2025
BACKGROUND: Piwi-interacting RNAs (piRNAs) are well established for monitoring and protecting the genome from transposons in germline cells. Recently, numerous studies provided evidence that piRNAs also play important roles in regulating mRNA transcr...
Piwi-Interacting RNA RNA, Small Interfering Mammals Computational Biology Animals Humans Mice Deep Learning
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LKLPDA: A Low-Rank Fast Kernel Learning Approach for Predicting piRNA-Disease Associations.

IEEE/ACM transactions on computational biology and bioinformatics Dec 10, 2024
Piwi-interacting RNAs (piRNAs) are increasingly recognized as potential biomarkers for various diseases. Investig-ating the complex relationship between piRNAs and diseases through computational methods can reduce the costs and risks associated with ...
Machine Learning Genetic Predisposition to Disease Algorithms RNA, Small Interfering Computational Biology Piwi-Interacting RNA Humans
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piRNA in Machine-Learning-Based Diagnostics of Colorectal Cancer.

Molecules (Basel, Switzerland) Sep 11, 2024
Objective biomarkers are crucial for early diagnosis to promote treatment and raise survival rates for diseases. With the smallest non-coding RNAs-piwi-RNAs (piRNAs)-and their transcripts, we sought to identify if these piRNAs could be used as biomar...
Piwi-Interacting RNA RNA, Small Interfering Humans Biomarkers, Tumor Machine Learning Bayes Theorem Colorectal Neoplasms Algorithms
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LSTM4piRNA: Efficient piRNA Detection in Large-Scale Genome Databases Using a Deep Learning-Based LSTM Network.

International journal of molecular sciences Oct 27, 2023
Piwi-interacting RNAs (piRNAs) are a new class of small, non-coding RNAs, crucial in the regulation of gene expression. Recent research has revealed links between piRNAs, viral defense mechanisms, and certain human cancers. Due to their clinical pote...
Piwi-Interacting RNA Algorithms Deep Learning Sequence Analysis, RNA Humans RNA, Small Interfering RNA, Small Untranslated
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iPiDA-LGE: a local and global graph ensemble learning framework for identifying piRNA-disease associations.

BMC biology May 9, 2025
BACKGROUND: Exploring piRNA-disease associations can help discover candidate diagnostic or prognostic biomarkers and therapeutic targets. Several computational methods have been presented for identifying associations between piRNAs and diseases. Howe...
Humans RNA, Small Interfering Piwi-Interacting RNA Ensemble Learning Genetic Predisposition to Disease Neural Networks, Computer Computational Biology
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