AIMC Topic: Secondary Metabolism

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Regulation and induction of fungal secondary metabolites: a comprehensive review.

Archives of microbiology Jul 1, 2025
Fungal secondary metabolites (SMs) represent a vast reservoir of bioactive compounds with immense therapeutic, agricultural, and industrial potential. These small molecules, including antibiotics, immunosuppressants, and anticancer agents, are synthe...
Fungi Multigene Family Gene Expression Regulation, Fungal Biosynthetic Pathways Secondary Metabolism Metabolic Engineering
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Employing Machine Learning Models to Predict Potential α-Glucosidase Inhibitory Plant Secondary Metabolites Targeting Type-2 Diabetes and Their Validation.

Journal of chemical information and modeling Oct 1, 2024
The need for new antidiabetic drugs is evident, considering the ongoing global burden of type-2 diabetes mellitus despite notable progress in drug discovery from laboratory research to clinical application. This study aimed to build machine learning ...
Humans Machine Learning Diabetes Mellitus, Type 2 Hypoglycemic Agents Plants alpha-Glucosidases Glycoside Hydrolase Inhibitors Secondary Metabolism
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Optimization of fungal secondary metabolites production via response surface methodology coupled with multi-parameter optimized artificial neural network model.

Bioresource technology Sep 20, 2024
Filamentous fungi's secondary metabolites (SMs) possess significant application owing to their distinct structure and diverse bioactivities, yet their restricted yield levels often hinder further research and application. The study developed a respon...
Neural Networks, Computer Algorithms Reproducibility of Results Models, Biological Fungi Secondary Metabolism
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Machine-Learning Analysis of Streptomyces coelicolor Transcriptomes Reveals a Transcription Regulatory Network Encompassing Biosynthetic Gene Clusters.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) Sep 12, 2024
Streptomyces produces diverse secondary metabolites of biopharmaceutical importance, yet the rate of biosynthesis of these metabolites is often hampered by complex transcriptional regulation. Therefore, a fundamental understanding of transcriptional ...
Machine Learning Gene Expression Profiling Transcriptome Gene Regulatory Networks Multigene Family Gene Expression Regulation, Bacterial Secondary Metabolism Streptomyces coelicolor
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Fruit-In-Sight: A deep learning-based framework for secondary metabolite class prediction using fruit and leaf images.

PloS one Aug 8, 2024
Fruits produce a wide variety of secondary metabolites of great economic value. Analytical measurement of the metabolites is tedious, time-consuming, and expensive. Additionally, metabolite concentrations vary greatly from tree to tree, making it dif...
Deep Learning Plant Leaves Chromatography, High Pressure Liquid Fruit Secondary Metabolism Myrtaceae
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IMG-ABC: A Knowledge Base To Fuel Discovery of Biosynthetic Gene Clusters and Novel Secondary Metabolites.

mBio Jul 14, 2015
UNLABELLED: In the discovery of secondary metabolites, analysis of sequence data is a promising exploration path that remains largely underutilized due to the lack of computational platforms that enable such a systematic approach on a large scale. In...
Computational Biology Knowledge Bases Multigene Family Biosynthetic Pathways Secondary Metabolism
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Deciphering the biosynthetic potential of microbial genomes using a BGC language processing neural network model.

Nucleic acids research Apr 10, 2025
Biosynthetic gene clusters (BGCs), key in synthesizing microbial secondary metabolites, are mostly hidden in microbial genomes and metagenomes. To unearth this vast potential, we present BGC-Prophet, a transformer-based language model for BGC predict...
Neural Networks, Computer Phylogeny Multigene Family Biosynthetic Pathways Genome, Bacterial Metagenome Secondary Metabolism Genome, Microbial
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