AIMC Topic: Metabolic Engineering

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Advances in microplastic mitigation: current progress and future directions.

Archives of microbiology
Microplastics transport toxins, disrupt microbial and nutrient cycles, bioaccumulate to cause oxidative stress and endocrine disruption, jeopardizing ecosystems and human health. Despite understanding microplastic origins, distribution, and microbial...

Microbial 1,3-Propanediol Production: A State-of-the-Art Review.

ACS synthetic biology
1,3-Propanediol (1,3-PD) is a notable industrial compound used in applications in materials, chemicals, pharmaceuticals, and the light industry. Because it is environmentally friendly and sustainable, the 1,3-PD biogenic synthesis has drawn a lot of ...

Monoclonal antibodies production in microbial systems: Current status, challenges and perspectives.

New biotechnology
Monoclonal antibodies (mAbs) serve as indispensable tools in diagnostics, clinical therapeutics, and biomedical research. However, their large-scale production faces significant challenges due to the high costs and lengthy timelines associated with c...

Programmable Biointerfaces and Adaptive Functionality in Next-Generation Green Nanomaterials.

ACS synthetic biology
Recent advances in green nanomaterials have primarily focused on mitigating toxicity through passive approaches, yet emerging technologies suggest a transformative paradigm shift toward programmable nanomaterials with dynamic biointerfaces. This Revi...

Challenges and Opportunities in Smart Biosensing for Biomanufacturing.

ACS synthetic biology
Traditional metabolic engineering has largely focused on the direct construction of synthetic metabolic pathways, often overlooking the critical role of regulation. In contrast, natural metabolic pathways are inherently tightly regulated, enabling ro...

Recent advances of muconic acid production using microbial synthetic biology.

Archives of microbiology
Muconic acid is a high-value intermediate with unique properties. Traditional methods for muconic acid production showed some disadvantages including expensive raw materials, environmentally sensitive, and high concentration of heavy metal catalysts....

Computational Strategies to Enhance Vitamin B Biosynthesis Potential of Microbes.

Current microbiology
Vitamin B is a vital nutrient for the normal functioning of many metabolic processes. It has a characteristic corrinoid ring structure with a cobalt ion. Its complex chemical structure demands 30 enzyme-catalyzed steps for synthesis. Deficiency of th...

Regulation and induction of fungal secondary metabolites: a comprehensive review.

Archives of microbiology
Fungal secondary metabolites (SMs) represent a vast reservoir of bioactive compounds with immense therapeutic, agricultural, and industrial potential. These small molecules, including antibiotics, immunosuppressants, and anticancer agents, are synthe...

Modeling host-pathway dynamics at the genome scale with machine learning.

Metabolic engineering
Pathway engineering offers a promising avenue for sustainable chemical production. The design of efficient production systems requires understanding complex host-pathway interactions that shape the metabolic phenotype. While genome-scale metabolic mo...

Enabling malic acid production from corn-stover hydrolysate in Lipomyces starkeyi via metabolic engineering and bioprocess optimization.

Microbial cell factories
BACKGROUND: Lipomyces starkeyi is an oleaginous yeast with a native metabolism well-suited for production of lipids and biofuels from complex lignocellulosic and waste feedstocks. Recent advances in genetic engineering tools have facilitated the deve...