AIMC Topic: Microfluidics
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Leukocyte differential based on an imaging and impedance flow cytometry of microfluidics coupled with deep neural networks.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Jan 4, 2024
The differential of leukocytes functions as the first indicator in clinical examinations. However, microscopic examinations suffered from key limitations of low throughputs in classifying leukocytes while commercially available hematology analyzers f...
Deep learning enhanced multiplex detection of viable foodborne pathogens in digital microfluidic chip.
Biosensors & bioelectronics
Nov 17, 2023
Culture plating is worldwide accepted as the gold standard for quantifying viable foodborne pathogens. However, it is time-consuming (1-2 days) and requires specialized laboratory and personnel. This study reported a deep learning enhanced digital mi...
Neural network execution using nicked DNA and microfluidics.
PloS one
Oct 19, 2023
DNA has been discussed as a potential medium for data storage. Potentially it could be denser, could consume less energy, and could be more durable than conventional storage media such as hard drives, solid-state storage, and optical media. However, ...
Current Status and Emerging Trends in Colorectal Cancer Screening and Diagnostics.
Biosensors
Oct 13, 2023
Colorectal cancer (CRC) is a prevalent and potentially fatal disease categorized based on its high incidences and mortality rates, which raised the need for effective diagnostic strategies for the early detection and management of CRC. While there ar...
Advance of microfluidic flow cytometry enabling high-throughput characterization of single-cell electrical and structural properties.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Oct 10, 2023
This paper reported a micro flow cytometer capable of high-throughput characterization of single-cell electrical and structural features based on constrictional microchannels and deep neural networks. When single cells traveled through microchannels ...
Artificial intelligence-accelerated high-throughput screening of antibiotic combinations on a microfluidic combinatorial droplet system.
Lab on a chip
Sep 13, 2023
Microfluidic platforms have been employed as an effective tool for drug screening and exhibit the advantages of lower reagent consumption, higher throughput and a higher degree of automation. Despite the great advancement, it remains challenging to s...
iCLOTS: open-source, artificial intelligence-enabled software for analyses of blood cells in microfluidic and microscopy-based assays.
Nature communications
Aug 18, 2023
While microscopy-based cellular assays, including microfluidics, have significantly advanced over the last several decades, there has not been concurrent development of widely-accessible techniques to analyze time-dependent microscopy data incorporat...
Computer Vision-Based Artificial Intelligence-Mediated Encoding-Decoding for Multiplexed Microfluidic Digital Immunoassay.
ACS nano
Jul 17, 2023
Digital immunoassays with multiplexed capacity, ultrahigh sensitivity, and broad affordability are urgently required in clinical diagnosis, food safety, and environmental monitoring. In this work, a multidimensional digital immunoassay has been devel...
Optical time-stretch imaging flow cytometry in the compressed domain.
Journal of biophotonics
May 18, 2023
Imaging flow cytometry based on optical time-stretch (OTS) imaging combined with a microfluidic chip attracts much attention in the large-scale single-cell analysis due to its high throughput, high precision, and label-free operation. Compressive sen...
High-throughput cell spheroid production and assembly analysis by microfluidics and deep learning.
SLAS technology
Mar 28, 2023
3D cell culture models are important tools in translational research but have been out of reach for high-throughput screening due to complexity, requirement of large cell numbers and inadequate standardization. Microfluidics and culture model miniatu...
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