AIMC Topic: Niemann-Pick C1 Protein

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Advances in mass spectrometry of lipids for the investigation of Niemann-pick type C disease.

Lipids in health and disease Jul 30, 2025
Niemann-Pick type C (NPC) disease is a devastating, fatal, neurodegenerative disease and a form of lysosomal storage disorder. It is caused by mutations in either NPC1 or NPC2 genes, leading to the accumulation of cholesterol and other lipids in the ...
Humans Biomarkers Animals Mass Spectrometry Lipids Mutation Cholesterol Lipid Metabolism Lipidomics Vesicular Transport Proteins Niemann-Pick Disease, Type C Niemann-Pick C1 Protein
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Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning.

Cell host & microbe Jan 15, 2025
Evidence suggests that bats are important hosts of filoviruses, yet the specific species involved remain largely unidentified. Niemann-Pick C1 (NPC1) is an essential entry receptor, with amino acid variations influencing viral susceptibility and spec...
Humans Machine Learning Animals Phylogeny Protein Binding Glycoproteins Ebolavirus Chiroptera Hemorrhagic Fever, Ebola Receptors, Virus Filoviridae Niemann-Pick C1 Protein Filoviridae Infections
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