AIMC Topic: Ebolavirus
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Single-cell image-based screens identify host regulators of Ebola virus infection dynamics.
Nature microbiology
Jul 24, 2025
Filoviruses such as Ebola virus (EBOV) give rise to frequent epidemics with high case fatality rates while therapeutic options remain limited. Earlier genetic screens aimed to identify potential drug targets for EBOV relied on systems that may not fu...
Prediction and characterisation of the human B cell response to a heterologous two-dose Ebola vaccine.
Nature communications
Jul 9, 2025
Ebola virus disease (EVD) outbreaks are increasing, posing significant threats to affected communities. Effective outbreak management depends on protecting frontline health workers, a key focus of EVD vaccination strategies. IgG specific to the viral...
In-silico evaluation of Azadirachta indica-derived Daucosterol against key viral proteins of Ebolavirus using ML and MD simulations approach.
Journal of biological physics
May 26, 2025
Ebola virus disease (EVD) is an acute life-threatening disease caused by highly pathogenic Ebolavirus (EBOV), with reported case fatality rates reaching 90%. There have been numerous EBOV outbreaks and epidemics since the first outbreak was reported ...
Assessing concordance between RNA-Seq and NanoString technologies in Ebola-infected nonhuman primates using machine learning.
BMC genomics
Apr 10, 2025
This study evaluates the concordance between RNA sequencing (RNA-Seq) and NanoString technologies for gene expression analysis in non-human primates (NHPs) infected with Ebola virus (EBOV). A detailed comparison of both platforms revealed a strong co...
Supervised learning approaches for predicting Ebola-Human Protein-Protein interactions.
Gene
Jan 17, 2025
The goal of this research work is to predict protein-protein interactions (PPIs) between the Ebola virus and the host who is at risk of infection. Since there are very limited databases available on the Ebola virus; we have prepared a comprehensive d...
Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning.
Cell host & microbe
Jan 15, 2025
Evidence suggests that bats are important hosts of filoviruses, yet the specific species involved remain largely unidentified. Niemann-Pick C1 (NPC1) is an essential entry receptor, with amino acid variations influencing viral susceptibility and spec...
The sweet detection of rolling circle amplification: Glucose-based electrochemical genosensor for the detection of viral nucleic acid.
Biosensors & bioelectronics
Dec 30, 2019
Herein, an isothermal padlock probe-based assay for the simple and portable detection of pathogens coupled with a glucose oxidase (GOx)-based electrochemical readout is reported. Infectious diseases remain a constant threat on a global scale, as in r...
An Ebola virus-centered knowledge base.
Database : the journal of biological databases and curation
Jun 8, 2015
Ebola virus (EBOV), of the family Filoviridae viruses, is a NIAID category A, lethal human pathogen. It is responsible for causing Ebola virus disease (EVD) that is a severe hemorrhagic fever and has a cumulative death rate of 41% in the ongoing epid...
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