AIMC Topic: Niemann-Pick Disease, Type C

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Advances in mass spectrometry of lipids for the investigation of Niemann-pick type C disease.

Lipids in health and disease Jul 30, 2025
Niemann-Pick type C (NPC) disease is a devastating, fatal, neurodegenerative disease and a form of lysosomal storage disorder. It is caused by mutations in either NPC1 or NPC2 genes, leading to the accumulation of cholesterol and other lipids in the ...
Humans Biomarkers Animals Mass Spectrometry Lipids Mutation Cholesterol Lipid Metabolism Lipidomics Vesicular Transport Proteins Niemann-Pick Disease, Type C Niemann-Pick C1 Protein
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Graphene Microelectrode Arrays, 4D Structured Illumination Microscopy, and a Machine Learning Spike Sorting Algorithm Permit the Analysis of Ultrastructural Neuronal Changes During Neuronal Signaling in a Model of Niemann-Pick Disease Type C.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) Sep 28, 2024
Simultaneously recording network activity and ultrastructural changes of the synapse is essential for advancing understanding of the basis of neuronal functions. However, the rapid millisecond-scale fluctuations in neuronal activity and the subtle su...
Machine Learning Algorithms Animals Rats Neurons Microscopy Graphite Hippocampus Microelectrodes Niemann-Pick Disease, Type C
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