AIMC Topic: Organ Specificity

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ME-Class2 reveals context dependent regulatory roles for 5-hydroxymethylcytosine.

Nucleic acids research Mar 18, 2019
Since the discovery of 5-hydroxymethylcytosine (5hmC) as a prominent DNA modification found in mammalian genomes, an emergent question has been what role this mark plays in gene regulation. 5hmC is hypothesized to function as an intermediate in the d...
Humans Machine Learning Brain Animals Mice Sequence Analysis, RNA Databases, Genetic Sulfites Datasets as Topic Methylation Promoter Regions, Genetic Organ Specificity Genome Genes 5-Methylcytosine
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Machine learning in computational biology to accelerate high-throughput protein expression.

Bioinformatics (Oxford, England) Aug 15, 2017
MOTIVATION: The Human Protein Atlas (HPA) enables the simultaneous characterization of thousands of proteins across various tissues to pinpoint their spatial location in the human body. This has been achieved through transcriptomics and high-throughp...
Humans Machine Learning Computational Biology Proteome Escherichia coli Solubility Gene Expression Regulation Organ Specificity
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Identification of human flap endonuclease 1 (FEN1) inhibitors using a machine learning based consensus virtual screening.

Molecular bioSystems Jul 25, 2017
Human Flap endonuclease1 (FEN1) is an enzyme that is indispensable for DNA replication and repair processes and inhibition of its Flap cleavage activity results in increased cellular sensitivity to DNA damaging agents (cisplatin, temozolomide, MMS, e...
Humans Machine Learning Colon Drug Discovery Antineoplastic Agents Cell Line, Tumor Epithelial Cells Cell Survival Gene Expression Inhibitory Concentration 50 Enzyme Inhibitors HEK293 Cells Databases, Chemical Organ Specificity Naphthoquinones Flap Endonucleases
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