AIMC Topic: Parkinson Disease

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Machine learning in neuroimaging and computational pathophysiology of Parkinson's disease: A comprehensive review and meta-analysis.

Asian journal of psychiatry
In recent years, machine learning and deep learning have shown potential for improving Parkinson's disease (PD) diagnosis, one of the most common neurodegenerative diseases. This comprehensive analysis examines machine learning and deep learning-base...

Speech signals-based Parkinson's disease diagnosis using hybrid autoencoder-LSTM models.

Computers in biology and medicine
Parkinson's disease (PD) is a neurodegenerative disorder that occurs as a result of a decrease in the chemical called dopamine in the brain. There is no definitive treatment for PD, but some medications used to control symptoms in the early stages ha...

Activity recognition in patients with tremor: Integrating time-length windows for enhanced detection.

Computers in biology and medicine
Pathological tremor significantly impairs daily activities and quality of life, particularly in conditions such as essential tremor and Parkinson's disease. The assessment and evaluation of tremor, along with its evolution with medication dosages, po...

Application of EEG microstates in Parkinson's disease.

Parkinsonism & related disorders
Electroencephalography (EEG) microstate analysis is a promising technique for detecting transient brain dynamics and identifying disease-specific biomarkers in Parkinson's disease (PD). By capturing subsecond fluctuations in brain activity with intri...

Robust computation of subcortical functional connectivity guided by quantitative susceptibility mapping: An application in Parkinson's disease diagnosis.

NeuroImage
Previous resting state functional MRI (rs-fMRI) analyses of the basal ganglia in Parkinson's disease heavily relied on T1-weighted imaging (T1WI) atlases. However, subcortical structures are characterized by subtle contrast differences, making their ...

Unraveling Parkinson's disease motor subtypes: A deep learning approach based on spatiotemporal dynamics of EEG microstates.

Neurobiology of disease
BACKGROUND: Despite prior studies on early-stage Parkinson's disease (PD) brain connectivity and temporal patterns, differences between tremor-dominant (TD) and postural instability/gait difficulty (PIGD) motor subtypes remain poorly understood. Our ...

Resting-state functional MRI metrics to detect freezing of gait in Parkinson's disease: a machine learning approach.

Computers in biology and medicine
Among the symptoms that can occur in Parkinson's disease (PD), Freezing of Gait (FOG) is a disabling phenomenon affecting a large proportion of patients, and it remains not fully understood. Accurate classification of FOG in PD is crucial for tailori...

A new lightweight deep learning model optimized with pruning and dynamic quantization to detect freezing gait on wearable devices.

Computers in biology and medicine
Freezing of gait (FoG) is a debilitating symptom of Parkinson's disease that severely impacts patients' mobility and quality of life. To minimize the risk of falls and injuries associated with FoG, it is crucial to develop highly accurate FoG detecti...

Computational screening of natural products as tryptophan 2,3-dioxygenase inhibitors: Insights from CNN-based QSAR, molecular docking, ADMET, and molecular dynamics simulations.

Computers in biology and medicine
Parkinson's disease (PD) is characterised by a complex array of motor, psychiatric, and gastrointestinal symptoms, many of which are linked to disruptions in neuroactive metabolites. Dysregulated activity of tryptophan 2,3-dioxygenase (TDO), a key en...

Medication versus globus pallidus internus deep brain stimulation in Parkinson's disease with deep learning video analysis of finger tapping.

Scientific reports
In advanced Parkinson's disease (PD), considerable number of patients receive deep brain stimulation (DBS) surgery, to alleviate symptoms not readily controlled by medication. However, the differential effects of medication and DBS on improving motor...