AIMC Topic: Penicillanic Acid

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Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients.

International journal of antimicrobial agents Dec 22, 2017
Dosing recommendations for continuous infusion of piperacillin, a broad-spectrum beta-lactam antibiotic, are mainly guided by outputs from population pharmacokinetic models constructed with intermittent infusion data. However, the probability of targ...
Humans Anti-Bacterial Agents Critical Illness Female Male Middle Aged Sepsis Microbial Sensitivity Tests Kidney Function Tests Drug Combinations Infusions, Intravenous Creatinine Pseudomonas aeruginosa Tazobactam Metabolic Clearance Rate Penicillanic Acid Piperacillin Pseudomonas Infections
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Simplifying Piperacillin/Tazobactam Dosing: Pharmacodynamics of Utilizing Only 4.5 or 3.375 g Doses for Patients With Normal and Impaired Renal Function.

Journal of pharmacy practice Dec 21, 2016
OBJECTIVES: To evaluate the pharmacodynamic exposure of piperacillin/tazobactam across the renal function range using 4.5 or 3.375 g dosing regimens.
Humans Anti-Bacterial Agents Microbial Sensitivity Tests Kidney Dose-Response Relationship, Drug Infusions, Intravenous Pseudomonas aeruginosa Enterobacteriaceae Renal Insufficiency Monte Carlo Method Penicillanic Acid Piperacillin Piperacillin, Tazobactam Drug Combination
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