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Piperacillin

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Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients.

International journal of antimicrobial agents 29277531
Dosing recommendations for continuous infusion of piperacillin, a broad-spectrum beta-lactam antibiotic, are mainly guided by outputs from population pharmacokinetic models constructed with intermittent infusion data. However, the probability of targ...
Anti-Bacterial Agents Creatinine Critical Illness Drug Combinations Female Humans Infusions, Intravenous Kidney Function Tests Male Metabolic Clearance Rate Microbial Sensitivity Tests Middle Aged Penicillanic Acid Piperacillin Pseudomonas aeruginosa Pseudomonas Infections Sepsis Tazobactam
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Simplifying Piperacillin/Tazobactam Dosing: Pharmacodynamics of Utilizing Only 4.5 or 3.375 g Doses for Patients With Normal and Impaired Renal Function.

Journal of pharmacy practice 29121839
OBJECTIVES: To evaluate the pharmacodynamic exposure of piperacillin/tazobactam across the renal function range using 4.5 or 3.375 g dosing regimens.
Anti-Bacterial Agents Dose-Response Relationship, Drug Enterobacteriaceae Humans Infusions, Intravenous Kidney Microbial Sensitivity Tests Monte Carlo Method Penicillanic Acid Piperacillin Piperacillin, Tazobactam Drug Combination Pseudomonas aeruginosa Renal Insufficiency
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