AIMC Topic: Receptor, Serotonin, 5-HT2C

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Computational design of thermostabilizing point mutations for G protein-coupled receptors.

eLife Jun 21, 2018
Engineering of GPCR constructs with improved thermostability is a key for successful structural and biochemical studies of this transmembrane protein family, targeted by 40% of all therapeutic drugs. Here we introduce a comprehensive computational ap...
Humans Machine Learning Animals Protein Binding Models, Molecular Gene Expression Kinetics Amino Acid Sequence Protein Stability Receptor, Serotonin, 5-HT2C Crystallography, X-Ray Binding Sites Protein Engineering Thermodynamics Sequence Alignment Sequence Homology, Amino Acid Protein Interaction Domains and Motifs Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Point Mutation Serotonin 5-HT2 Receptor Agonists Serotonin 5-HT2 Receptor Antagonists
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Principi di farmacodinamica e farmacocinetica nello switch tra antipsicotici: focus su cariprazina.

Rivista di psichiatria Jan 1, 2019
Cariprazina {RGH-188; trans-N- [4- [2- [4- (2,3-diclorofenil) piperazin-1-il] etil] cicloesil] -N_, N_-dimetilurea cloridrato} รจ un antipsicotico atipico di nuova generazione, con un originale profilo farmacodinamico e farmacocinetico. Cariprazina ha...
Humans Time Factors Piperazines Drug Interactions Schizophrenia Half-Life Anhedonia Antipsychotic Agents Cognition Disorders Cytochrome P-450 CYP2D6 Inducers Cytochrome P-450 CYP3A Inducers Drug Substitution Ketoconazole Receptor, Serotonin, 5-HT2A Receptor, Serotonin, 5-HT2C
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