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Receptor, Serotonin, 5-HT2C

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Principi di farmacodinamica e farmacocinetica nello switch tra antipsicotici: focus su cariprazina.

Rivista di psichiatria 32310932
Cariprazina {RGH-188; trans-N- [4- [2- [4- (2,3-diclorofenil) piperazin-1-il] etil] cicloesil] -N_, N_-dimetilurea cloridrato} รจ un antipsicotico atipico di nuova generazione, con un originale profilo farmacodinamico e farmacocinetico. Cariprazina ha...
Anhedonia Antipsychotic Agents Cognition Disorders Cytochrome P-450 CYP2D6 Inducers Cytochrome P-450 CYP3A Inducers Drug Interactions Drug Substitution Half-Life Humans Ketoconazole Piperazines Receptor, Serotonin, 5-HT2A Receptor, Serotonin, 5-HT2C Schizophrenia Time Factors
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Computational design of thermostabilizing point mutations for G protein-coupled receptors.

eLife 29927385
Engineering of GPCR constructs with improved thermostability is a key for successful structural and biochemical studies of this transmembrane protein family, targeted by 40% of all therapeutic drugs. Here we introduce a comprehensive computational ap...
Amino Acid Sequence Animals Binding Sites Crystallography, X-Ray Gene Expression Humans Kinetics Machine Learning Models, Molecular Point Mutation Protein Binding Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Protein Engineering Protein Interaction Domains and Motifs Protein Stability Receptor, Serotonin, 5-HT2C Sequence Alignment Sequence Homology, Amino Acid Serotonin 5-HT2 Receptor Agonists Serotonin 5-HT2 Receptor Antagonists Thermodynamics
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