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Ketoconazole

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Principi di farmacodinamica e farmacocinetica nello switch tra antipsicotici: focus su cariprazina.

Rivista di psichiatria 32310932
Cariprazina {RGH-188; trans-N- [4- [2- [4- (2,3-diclorofenil) piperazin-1-il] etil] cicloesil] -N_, N_-dimetilurea cloridrato} è un antipsicotico atipico di nuova generazione, con un originale profilo farmacodinamico e farmacocinetico. Cariprazina ha...
Anhedonia Antipsychotic Agents Cognition Disorders Cytochrome P-450 CYP2D6 Inducers Cytochrome P-450 CYP3A Inducers Drug Interactions Drug Substitution Half-Life Humans Ketoconazole Piperazines Receptor, Serotonin, 5-HT2A Receptor, Serotonin, 5-HT2C Schizophrenia Time Factors
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Physiological based pharmacokinetic modeling to estimate in vivo Ki of ketoconazole on renal P-gp using human drug-drug interaction study result of fesoterodine and ketoconazole.

Drug metabolism and pharmacokinetics 29338933
This study was conducted to estimate in vivo inhibition constant (Ki) of ketoconazole on renal P-glycoprotein (P-gp) using human drug-drug interaction (DDI) study result of fesoterodine and ketoconazole. Fesoterodine is a prodrug which is extensively...
ATP Binding Cassette Transporter, Subfamily B, Member 1 Benzhydryl Compounds Cross-Over Studies Cytochrome P-450 CYP3A Inhibitors Drug Interactions Humans Ketoconazole Kidney Liver Male Models, Biological Muscarinic Antagonists
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