AIMC Topic: Receptors, Dopamine

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An interpretable machine learning model for selectivity of small-molecules against homologous protein family.

Future medicinal chemistry Sep 28, 2022
In the early stages of drug discovery, various experimental and computational methods are used to measure the specificity of small molecules against a target protein. The selectivity of small molecules remains a challenge leading to off-target side ...
Neural Networks, Computer Machine Learning Drug Discovery Proteins Receptors, Dopamine
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Spine dynamics in the brain, mental disorders and artificial neural networks.

Nature reviews. Neuroscience May 28, 2021
In the brain, most synapses are formed on minute protrusions known as dendritic spines. Unlike their artificial intelligence counterparts, spines are not merely tuneable memory elements: they also embody algorithms that implement the brain's ability ...
Humans Neural Networks, Computer Artificial Intelligence Machine Learning Algorithms Mental Disorders Brain Animals Neuronal Plasticity Models, Neurological Memory, Short-Term Reward Synapses Species Specificity Dopamine Dendritic Spines Optogenetics Mental Processes Neurotransmitter Agents Receptors, Dopamine
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Global and local excitation and inhibition shape the dynamics of the cortico-striatal-thalamo-cortical pathway.

Scientific reports Aug 8, 2017
The cortico-striatal-thalamo-cortical (CSTC) pathway is a brain circuit that controls movement execution, habit formation and reward. Hyperactivity in the CSTC pathway is involved in obsessive compulsive disorder (OCD), a neuropsychiatric disorder ch...
Humans Neural Networks, Computer Animals Reward Synapses Cerebral Cortex Species Specificity Connectome Corpus Striatum gamma-Aminobutyric Acid Thalamus Synaptic Transmission GABAergic Neurons Neural Inhibition Glutamic Acid Rodentia Cortical Excitability Receptors, Dopamine
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