AIMC Topic: Receptors, Opioid

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Opioid growth factor receptor overexpression exerts anti-hepatocellular carcinoma effects by activating P16 and P21 to inhibit proliferation and migration of HepG2 cells.

Folia histochemica et cytobiologica Jan 13, 2025
INTRODUCTION: Hepatocellular carcinoma (HCC) is the sixth most common type of cancer and the second leading cause of cancer death worldwide [19]. Opioid growth factor (OGF) has been shown to exhibit antitumour potential, binding to OGF receptor (OGFr...
Humans Animals Male Liver Neoplasms Carcinoma, Hepatocellular Mice Cell Proliferation Hep G2 Cells Cell Movement Mice, Nude Mice, Inbred BALB C Cyclin-Dependent Kinase Inhibitor p21 Receptors, Opioid Cyclin-Dependent Kinase Inhibitor p16 Apoptosis
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Multiobjective Molecular Optimization for Opioid Use Disorder Treatment Using Generative Network Complex.

Journal of medicinal chemistry Aug 25, 2023
Opioid use disorder (OUD) has emerged as a significant global public health issue, necessitating the discovery of new medications. In this study, we propose a deep generative model that combines a stochastic differential equation (SDE)-based diffusio...
Humans Machine Learning Receptors, Opioid Diffusion Opioid-Related Disorders
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[Endogenous nocciceptin/orphanin FQ affect ischemic arrhythmias in rats through Raf kinase inhibitor protein].

Zhonghua wei zhong bing ji jiu yi xue Dec 1, 2019
OBJECTIVE: To investigate whether endogenous nociceptin/orphanin FQ (N/OFQ) can inhibit arrhythmia and expression of β-adrenergic receptor (β-AR) on the surface of myocardial cell membrane in acute myocardial ischemia rats by Raf kinase inhibitory pr...
Animals Male Rats Rats, Sprague-Dawley Receptors, Opioid Arrhythmias, Cardiac Opioid Peptides Phosphatidylethanolamine Binding Protein Nociceptin
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