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Receptors, Opioid

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Opioid growth factor receptor overexpression exerts anti-hepatocellular carcinoma effects by activating P16 and P21 to inhibit proliferation and migration of HepG2 cells.

Folia histochemica et cytobiologica
INTRODUCTION: Hepatocellular carcinoma (HCC) is the sixth most common type of cancer and the second leading cause of cancer death worldwide [19]. Opioid growth factor (OGF) has been shown to exhibit antitumour potential, binding to OGF receptor (OGFr...

[Endogenous nocciceptin/orphanin FQ affect ischemic arrhythmias in rats through Raf kinase inhibitor protein].

Zhonghua wei zhong bing ji jiu yi xue
OBJECTIVE: To investigate whether endogenous nociceptin/orphanin FQ (N/OFQ) can inhibit arrhythmia and expression of β-adrenergic receptor (β-AR) on the surface of myocardial cell membrane in acute myocardial ischemia rats by Raf kinase inhibitory pr...

Multiobjective Molecular Optimization for Opioid Use Disorder Treatment Using Generative Network Complex.

Journal of medicinal chemistry
Opioid use disorder (OUD) has emerged as a significant global public health issue, necessitating the discovery of new medications. In this study, we propose a deep generative model that combines a stochastic differential equation (SDE)-based diffusio...