AIMC Topic: Cyclin-Dependent Kinase Inhibitor p21

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Opioid growth factor receptor overexpression exerts anti-hepatocellular carcinoma effects by activating P16 and P21 to inhibit proliferation and migration of HepG2 cells.

Folia histochemica et cytobiologica Jan 13, 2025
INTRODUCTION: Hepatocellular carcinoma (HCC) is the sixth most common type of cancer and the second leading cause of cancer death worldwide [19]. Opioid growth factor (OGF) has been shown to exhibit antitumour potential, binding to OGF receptor (OGFr...
Apoptosis Cyclin-Dependent Kinase Inhibitor p16 Liver Neoplasms Hep G2 Cells Cell Proliferation Cyclin-Dependent Kinase Inhibitor p21 Mice Cell Movement Mice, Inbred BALB C Receptors, Opioid Carcinoma, Hepatocellular Mice, Nude Animals Male Humans
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CDKN1A and EGR1 are key genes for endoplasmic reticulum stress-induced ferroptosis in MASH.

Free radical biology & medicine Aug 16, 2025
Metabolic dysfunction-associated steatohepatitis (MASH) is a complex liver disease whose pathogenesis involving endoplasmic reticulum (ER) stress and ferroptosis. However, key regulatory genes remain poorly understood, hindering the development of ef...
Animals Male Humans Ferroptosis Non-alcoholic Fatty Liver Disease Diet, High-Fat Phenylenediamines Early Growth Response Protein 1 Endoplasmic Reticulum Stress Cyclin-Dependent Kinase Inhibitor p21 Liver Hep G2 Cells Gene Expression Regulation Mice, Inbred C57BL Mice Fatty Liver Disease Models, Animal
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[Role of high mobility group protein B1 in 
IL-1α-induced endothelial cell senescence].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences Dec 28, 2017
To explore the effect of interleukin-1α (IL-1α) on the senescence of human umbilical vein endothelial cells (HUVECs) and the function of high mobility group protein 1 (HMGB1).
 Methods: HUVECs were randomly divided into a control group, a IL-1α group...
beta-Galactosidase Cyclin-Dependent Kinase Inhibitor p21 Humans Tumor Suppressor Protein p53 RNA, Messenger HMGB1 Protein Human Umbilical Vein Endothelial Cells Sirtuin 1 Interleukin-1alpha Cellular Senescence Cyclin-Dependent Kinase Inhibitor p16 Random Allocation
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Effect of Fanbaicao (Herba Potentillae Discoloris) oil on the expression of p21 and CDK4 in HepG2 cells.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Aug 1, 2016
OBJECTIVE: To research the anti-cancer mechanism of the Traditional Chinese Medicine Fanbaicao (Herba Potentillae Discoloris) oil in the human hepatoma cell line HepG2.
Cell Cycle Cyclin-Dependent Kinase 4 Drugs, Chinese Herbal Potentilla Hep G2 Cells Apoptosis Cyclin-Dependent Kinase Inhibitor p21 Liver Neoplasms Cell Proliferation Humans
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