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Receptors, Purinergic P2

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Immune profile of the tumor microenvironment and the identification of a four-gene signature for lung adenocarcinoma.

Aging
The composition and relative abundances of immune cells in the tumor microenvironment are key factors affecting the progression of lung adenocarcinomas (LUADs) and the efficacy of immunotherapy. Using the cancer gene expression dataset from The Cance...

Machine learning-aided search for ligands of P2Y and other P2Y receptors.

Purinergic signalling
The P2Y receptor, activated by uridine diphosphate (UDP), is a target for antagonists in inflammatory, neurodegenerative, and metabolic disorders, yet few potent and selective antagonists are known to date. This prompted us to use machine learning as...