AIMC Topic: Saccharomyces cerevisiae

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Automated segmentation of cell organelles in volume electron microscopy using deep learning.

Microscopy research and technique
Recent advances in computing power triggered the use of artificial intelligence in image analysis in life sciences. To train these algorithms, a large enough set of certified labeled data is required. The trained neural network is then capable of pro...

A high-speed microscopy system based on deep learning to detect yeast-like fungi cells in blood.

Bioanalysis
Blood-invasive fungal infections can cause the death of patients, while diagnosis of fungal infections is challenging. A high-speed microscopy detection system was constructed that included a microfluidic system, a microscope connected to a high-sp...

FUN-PROSE: A deep learning approach to predict condition-specific gene expression in fungi.

PLoS computational biology
mRNA levels of all genes in a genome is a critical piece of information defining the overall state of the cell in a given environmental condition. Being able to reconstruct such condition-specific expression in fungal genomes is particularly importan...

Automated quantification of vacuole fusion and lipophagy in from fluorescence and cryo-soft X-ray microscopy data using deep learning.

Autophagy
During starvation in the yeast vacuolar vesicles fuse and lipid droplets (LDs) can become internalized into the vacuole in an autophagic process named lipophagy. There is a lack of tools to quantitatively assess starvation-induced vacuole fusion and...

Prediction of Multiple Types of RNA Modifications via Biological Language Model.

IEEE/ACM transactions on computational biology and bioinformatics
It has been demonstrated that RNA modifications play essential roles in multiple biological processes. Accurate identification of RNA modifications in the transcriptome is critical for providing insights into the biological functions and mechanisms. ...

Prediction of Protein-Protein Interactions Using Vision Transformer and Language Model.

IEEE/ACM transactions on computational biology and bioinformatics
The knowledge of protein-protein interaction (PPI) helps us to understand proteins' functions, the causes and growth of several diseases, and can aid in designing new drugs. The majority of existing PPI research has relied mainly on sequence-based ap...

Is AI essential? Examining the need for deep learning in image-activated sorting of .

Lab on a chip
Artificial intelligence (AI) has become a focal point across a multitude of societal sectors, with science not being an exception. Particularly in the life sciences, imaging flow cytometry has increasingly integrated AI for automated management and c...

TidyTron: Reducing lab waste using validated wash-and-reuse protocols for common plasticware in Opentrons OT-2 lab robots.

SLAS technology
Every year biotechnology labs generate a combined total of ∼5.5 million tons of plastic waste. As the global bioeconomy expands, biofoundries will inevitably increase plastic consumption in-step with synthetic biology scaling. Decontamination and reu...

Label-Free Intracellular Multi-Specificity in Yeast Cells by Phase-Contrast Tomographic Flow Cytometry.

Small methods
In-flow phase-contrast tomography provides a 3D refractive index of label-free cells in cytometry systems. Its major limitation, as with any quantitative phase imaging approach, is the lack of specificity compared to fluorescence microscopy, thus res...

A novel hybrid CNN and BiGRU-Attention based deep learning model for protein function prediction.

Statistical applications in genetics and molecular biology
Proteins are the building blocks of all living things. Protein function must be ascertained if the molecular mechanism of life is to be understood. While CNN is good at capturing short-term relationships, GRU and LSTM can capture long-term dependenci...