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Selective Estrogen Receptor Modulators

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Population pharmacokinetic/pharmacodynamic assessment of pharmacological effect of a selective estrogen receptor β agonist on total testosterone in healthy men.

Clinical pharmacology in drug development 27136911
BACKGROUND: LY500307 is a highly selective estrogen receptor β (ERβ) agonist, which loses its selectivity at high dose and leads to undesirable suppression of total testosterone (TT) concentration. The objective of the present analysis was to define ...
Administration, Oral Adult Benzopyrans Biomarkers Circadian Rhythm Cross-Over Studies Drug Administration Schedule Estrogen Receptor beta Fourier Analysis Healthy Volunteers Humans London Male Middle Aged Models, Biological Nonlinear Dynamics Selective Estrogen Receptor Modulators Single-Blind Method Testosterone Young Adult
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