AIMC Topic: Selective Estrogen Receptor Modulators

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Population pharmacokinetic/pharmacodynamic assessment of pharmacological effect of a selective estrogen receptor β agonist on total testosterone in healthy men.

Clinical pharmacology in drug development Jun 8, 2015
BACKGROUND: LY500307 is a highly selective estrogen receptor β (ERβ) agonist, which loses its selectivity at high dose and leads to undesirable suppression of total testosterone (TT) concentration. The objective of the present analysis was to define ...
Humans Biomarkers Young Adult Adult Male Middle Aged Testosterone Single-Blind Method Models, Biological Circadian Rhythm Administration, Oral Cross-Over Studies Healthy Volunteers Nonlinear Dynamics Benzopyrans Drug Administration Schedule Estrogen Receptor beta Fourier Analysis London Selective Estrogen Receptor Modulators
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