AIMC Topic: Ubiquitin Thiolesterase

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Prediction of molecular subclasses of uveal melanoma by deep learning using routine haematoxylin-eosin-stained tissue slides.

Histopathology Jul 1, 2024
AIMS: Uveal melanoma has a high propensity to metastasize. Prognosis is associated with specific driver mutations and copy number variations, and these can only be obtained after genetic testing. In this study we evaluated the efficacy of patient out...
Prognosis Retrospective Studies Humans Aged Aged, 80 and over Female Melanoma Hematoxylin RNA Splicing Factors Tumor Suppressor Proteins Eosine Yellowish-(YS) Uveal Melanoma Eukaryotic Initiation Factor-1 Uveal Neoplasms Ubiquitin Thiolesterase Deep Learning Staining and Labeling Mutation Phosphoproteins Male Middle Aged Adult
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Utilizing machine learning to identify nifuroxazide as an inhibitor of ubiquitin-specific protease 21 in a drug repositioning strategy.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Mar 21, 2024
Ubiquitin-specific protease (USP), an enzyme catalyzing protein deubiquitination, is involved in biological processes related to metabolic disorders and cancer proliferation. We focused on constructing predictive models tailored to unveil compounds b...
Ubiquitin Thiolesterase Hep G2 Cells Drug Repositioning Hydroxybenzoates Nitrofurans Animals Mice Machine Learning Humans
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Piloting a Deep Learning Model for Predicting Nuclear BAP1 Immunohistochemical Expression of Uveal Melanoma from Hematoxylin-and-Eosin Sections.

Translational vision science & technology Sep 1, 2020
BACKGROUND: Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Monosomy 3 and mutation are strong prognostic factors predicting metastatic risk in UM. Nuclear BAP1 (nBAP1) expression is a close immunohistochemical surro...
Ubiquitin Thiolesterase Uveal Melanoma Hematoxylin Uveal Neoplasms Humans Eosine Yellowish-(YS) Deep Learning Artificial Intelligence Tumor Suppressor Proteins Melanoma Adult
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Comprehensive Molecular and Pathologic Evaluation of Transitional Mesothelioma Assisted by Deep Learning Approach: A Multi-Institutional Study of the International Mesothelioma Panel from the MESOPATH Reference Center.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer Mar 9, 2020
INTRODUCTION: Histologic subtypes of malignant pleural mesothelioma are a major prognostic indicator and decision denominator for all therapeutic strategies. In an ambiguous case, a rare transitional mesothelioma (TM) pattern may be diagnosed by path...
Ubiquitin Thiolesterase Mesothelioma Homozygote Deep Learning Humans Sequence Deletion Lung Neoplasms Tumor Suppressor Proteins
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Intratumoral Resolution of Driver Gene Mutation Heterogeneity in Renal Cancer Using Deep Learning.

Cancer research Aug 3, 2022
UNLABELLED: Intratumoral heterogeneity arising from tumor evolution poses significant challenges biologically and clinically. Dissecting this complexity may benefit from deep learning (DL) algorithms, which can infer molecular features from ubiquitou...
Humans Animals Kidney Neoplasms Mutation Ubiquitin Thiolesterase Carcinoma, Renal Cell Tumor Suppressor Proteins Deep Learning Nuclear Proteins
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