This study focuses on predicting the solubility of paracetamol and density of solvent using temperature (T) and pressure (P) as inputs. The process for production of the drug is supercritical technique in which the focus was on theoretical investigat...
International journal of pharmaceutics
Oct 13, 2025
The disintegration behaviour of pharmaceutical tablets is a critical quality attribute influencing drug release, yet predicting it from formulation and processing parameters remains challenging due to complex underlying mechanisms. This work presents...
Ciprofloxacin (CFX) is a potent antibiotic for respiratory infections, but its poor solubility and high crystallinity limit its effectiveness in dry powder inhaler (DPI) delivery. Although soluble forms such as CFX hydrochloride are available, their ...
We investigated solubility variations of a medication in supercritical carbon dioxide with an insight into preparation of nanomedicines with improved aqueous solubility. As the case study, the solubility of famotidine (FAM) medicine in sc-CO (supercr...
Poor oral bioavailability in most modern pharmaceuticals is primarily caused by poor aqueous solubility. Most NCEs (New Chemical Entities) and nearly 40% of drugs on the market fall into either Biopharmaceutical Classification System (BCS) class II o...
International journal of pharmaceutics
Aug 24, 2025
PURPOSE: The development of a novel lipid-based formulation for apalutamide, a potent androgen receptor inhibitor for non-metastatic castration-resistant prostate cancer (nmCRPC), is explored in this study.
This work presents a comprehensive study on the prediction of phenytoin solubility at supercritical state using advanced techniques including machine learning analysis. The solubility of small-molecule pharmaceutical was analyzed and calculated to en...
Journal of controlled release : official journal of the Controlled Release Society
Aug 16, 2025
Amorphous solid dispersions (ASDs) have emerged as a pivotal strategy in enhancing the dissolution profiles of poorly water-soluble drugs. Although the apparent dissolution rate (both molecular and colloidal drugs) within ASDs has been determined in ...
The field of solid-state pharmaceutics comprises a broad range of investigations into various structural aspects of pharmaceutical solids, establishing a rational structure-property correlation. These solid systems allow the tunability of the physico...
Journal of chemical information and modeling
Aug 10, 2025
Aqueous solubility is one key property of a chemical compound that determines its possible use in different applications, from drug development to materials sciences. In this work, we present a model for the prediction of aqueous solubility that leve...
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