AIMC Topic: Spike Glycoprotein, Coronavirus

Clear Filters Showing 41 to 50 of 59 articles

An in silico deep learning approach to multi-epitope vaccine design: a SARS-CoV-2 case study.

Scientific reports Feb 5, 2021
The rampant spread of COVID-19, an infectious disease caused by SARS-CoV-2, all over the world has led to over millions of deaths, and devastated the social, financial and political entities around the world. Without an existing effective medical the...
Humans Drug Design Deep Learning COVID-19 Vaccines Spike Glycoprotein, Coronavirus Computational Biology COVID-19 SARS-CoV-2 Epitopes, T-Lymphocyte Molecular Docking Simulation Allergens Codon Usage Solubility Protein Conformation Immunogenicity, Vaccine Epitopes, B-Lymphocyte T-Lymphocytes, Helper-Inducer Models, Molecular Vaccines, Subunit Mutation T-Lymphocytes, Cytotoxic RNA, Viral Molecular Dynamics Simulation
View on PubMed DOI

Predicting Potential SARS-COV-2 Drugs-In Depth Drug Database Screening Using Deep Neural Network Framework SSnet, Classical Virtual Screening and Docking.

International journal of molecular sciences Feb 4, 2021
Severe Acute Respiratory Syndrome Corona Virus 2 has altered life on a global scale. A concerted effort from research labs around the world resulted in the identification of potential pharmaceutical treatments for CoVID-19 using existing drugs, as we...
COVID-19 Drug Treatment Angiotensin-Converting Enzyme 2 Databases, Pharmaceutical Antiviral Agents Spike Glycoprotein, Coronavirus Drug Repositioning Drug Evaluation, Preclinical Humans Neural Networks, Computer Machine Learning SARS-CoV-2 Molecular Docking Simulation Drug Discovery COVID-19 Algorithms
View on PubMed DOI

Artificial intelligence predicts the immunogenic landscape of SARS-CoV-2 leading to universal blueprints for vaccine designs.

Scientific reports Dec 23, 2020
The global population is at present suffering from a pandemic of Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The goal of this study was to use artificial intellige...
Humans Machine Learning Software Pandemics SARS-CoV-2 Epitopes, T-Lymphocyte COVID-19 Vaccines COVID-19 Algorithms Haplotypes Immunogenicity, Vaccine HLA Antigens Spike Glycoprotein, Coronavirus Proteomics Drug Evaluation, Preclinical Proteome Alleles Mutation Amino Acid Sequence
View on PubMed DOI

Repurposing potential of FDA-approved and investigational drugs for COVID-19 targeting SARS-CoV-2 spike and main protease and validation by machine learning algorithm.

Chemical biology & drug design Dec 22, 2020
The present study aimed to assess the repurposing potential of existing antiviral drug candidates (FDA-approved and investigational) against SARS-CoV-2 target proteins that facilitates viral entry and replication into the host body. To evaluate molec...
Viral Matrix Proteins COVID-19 Drug Treatment Binding Sites Protease Inhibitors Deoxyadenosines Cell Line Cell Survival Drug Repositioning Structure-Activity Relationship Humans Machine Learning Molecular Docking Simulation Antiviral Agents Spike Glycoprotein, Coronavirus COVID-19 SARS-CoV-2
View on PubMed DOI

Identification and validation of 174 COVID-19 vaccine candidate epitopes reveals low performance of common epitope prediction tools.

Scientific reports Nov 24, 2020
The outbreak of SARS-CoV-2 (2019-nCoV) virus has highlighted the need for fast and efficacious vaccine development. Stimulation of a proper immune response that leads to protection is highly dependent on presentation of epitopes to circulating T-cell...
Machine Learning Humans SARS-CoV-2 COVID-19 Epitopes, T-Lymphocyte Peptides Alleles Histocompatibility Antigens Class I Base Sequence COVID-19 Vaccines Histocompatibility Antigens Class II Spike Glycoprotein, Coronavirus Computational Biology HLA Antigens
View on PubMed DOI

Machine learning methods accurately predict host specificity of coronaviruses based on spike sequences alone.

Biochemical and biophysical research communications Sep 18, 2020
Coronaviruses infect many animals, including humans, due to interspecies transmission. Three of the known human coronaviruses: MERS, SARS-CoV-1, and SARS-CoV-2, the pathogen for the COVID-19 pandemic, cause severe disease. Improved methods to predict...
Humans Machine Learning Animals Spike Glycoprotein, Coronavirus Computational Biology Host Specificity Coronavirus
View on PubMed DOI

Screening of Therapeutic Agents for COVID-19 Using Machine Learning and Ensemble Docking Studies.

The journal of physical chemistry letters Aug 14, 2020
The current pandemic demands a search for therapeutic agents against the novel coronavirus SARS-CoV-2. Here, we present an efficient computational strategy that combines machine learning (ML)-based models and high-fidelity ensemble docking studies to...
Drug Evaluation, Preclinical Protein Conformation Hydrogen Bonding Humans Betacoronavirus Molecular Docking Simulation Machine Learning Antiviral Agents Spike Glycoprotein, Coronavirus SARS-CoV-2
View on PubMed DOI

Detection of S1 spike protein in CD16+ monocytes up to 245 days in SARS-CoV-2-negative post-COVID-19 vaccine syndrome (PCVS) individuals.

Human vaccines & immunotherapeutics Dec 1, 2025
Despite over 13 billion SARS-CoV-2 vaccine doses administered globally, persistent post-vaccination symptoms, termed post-COVID-19 vaccine syndrome (PCVS), resemble post-acute sequelae of COVID-19 (PASC). Symptoms like cardiac, vascular, and neurolog...
COVID-19 Cytokines Female SARS-CoV-2 Humans Aged Monocytes COVID-19 Vaccines Adult GPI-Linked Proteins Spike Glycoprotein, Coronavirus Male Receptors, IgG Middle Aged
View on PubMed DOI

Computationally designed proteins mimic antibody immune evasion in viral evolution.

Immunity Jun 10, 2025
Recurrent waves of viral infection necessitate vaccines and therapeutics that remain effective against emerging viruses. Our ability to evaluate interventions is currently limited to assessments against past or circulating variants, which likely diff...
Antibodies, Neutralizing Angiotensin-Converting Enzyme 2 COVID-19 Vaccines Immune Evasion Humans COVID-19 SARS-CoV-2 Animals Antibodies, Viral Spike Glycoprotein, Coronavirus Evolution, Molecular
View on PubMed DOI

Using Machine Learning to Analyze Molecular Dynamics Simulations of Biomolecules.

The journal of physical chemistry. B Jun 5, 2025
Machine learning (ML) techniques have become powerful tools in both industrial and academic settings. Their ability to facilitate analysis of complex data and generation of predictive insights is transforming how scientific problems are approached ac...
Spike Glycoprotein, Coronavirus Molecular Dynamics Simulation Angiotensin-Converting Enzyme 2 Machine Learning SARS-CoV-2 Protein Binding Humans
View on PubMed DOI
Popular Topics
Recent Journals