AIMC Topic: Technology, Pharmaceutical

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Roller compaction: Measuring ribbon porosity by terahertz spectroscopy and machine learning.

International journal of pharmaceutics
Roller compaction is a crucial unit operation in pharmaceutical manufacturing, with its ribbon porosity widely recognised as a critical quality attribute. Terahertz spectroscopy has emerged as a fast and non-destructive technique to measure porosity ...

Evaluation of floatability characteristics of gastroretentive tablets using VIS imaging with artificial neural networks.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Gastroretentive dosage forms are recommended for several active substances because it is often necessary for the drug to be released from the carrier system into the stomach over an extended period. Among gastroretentive dosage forms, floating tablet...

Leveraging artificial intelligence for better translation of fibre-based pharmaceutical systems into real-world benefits.

Pharmaceutical development and technology
The increasing prominence of biologics in the pharmaceutical market requires more advanced delivery systems to deliver these delicate and complex drug molecules for better therapeutic outcomes. Fibre technology has emerged as a promising approach for...

The Artificial Intelligence-Powered New Era in Pharmaceutical Research and Development: A Review.

AAPS PharmSciTech
Currently, artificial intelligence (AI), machine learning (ML), and deep learning (DL) are gaining increased interest in many fields, particularly in pharmaceutical research and development, where they assist in decision-making in complex situations....

3D printed dosage forms, where are we headed?

Expert opinion on drug delivery
INTRODUCTION: 3D Printing (3DP) is an innovative fabrication technology that has gained enormous popularity through its paradigm shifts in manufacturing in several disciplines, including healthcare. In this past decade, we have witnessed the impact o...

Hybrid modeling of T-shaped partial least squares regression and transfer learning for formulation and manufacturing process development of new drug products.

International journal of pharmaceutics
T-shaped partial least squares regression (T-PLSR) is a valuable machine learning technique for the formulation and manufacturing process development of new drug products. An accurate T-PLSR model requires experimental data with multiple formulations...

Smart laser Sintering: Deep Learning-Powered powder bed fusion 3D printing in precision medicine.

International journal of pharmaceutics
Medicines remain ineffective for over 50% of patients due to conventional mass production methods with fixed drug dosages. Three-dimensional (3D) printing, specifically selective laser sintering (SLS), offers a potential solution to this challenge, a...

Automated Tomographic Assessment of Structural Defects of Freeze-Dried Pharmaceuticals.

AAPS PharmSciTech
The topology and surface characteristics of lyophilisates significantly impact the stability and reconstitutability of freeze-dried pharmaceuticals. Consequently, visual quality control of the product is imperative. However, this procedure is not onl...

Exploring the Potential of Artificial Intelligence as a Facilitating Tool for Formulation Development in Fluidized Bed Processor: a Comprehensive Review.

AAPS PharmSciTech
This in-depth study looks into how artificial intelligence (AI) could be used to make formulation development easier in fluidized bed processes (FBP). FBP is complex and involves numerous variables, making optimization challenging. Various AI techniq...

AI-driven design of customized 3D-printed multi-layer capsules with controlled drug release profiles for personalized medicine.

International journal of pharmaceutics
Personalized medicine aims to effectively and efficiently provide customized drugs that cater to diverse populations, which is a significant yet challenging task. Recently, the integration of artificial intelligence (AI) and three-dimensional (3D) pr...