AIMC Topic: Viral Proteins
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In-silico evaluation of Azadirachta indica-derived Daucosterol against key viral proteins of Ebolavirus using ML and MD simulations approach.
Journal of biological physics
May 26, 2025
Ebola virus disease (EVD) is an acute life-threatening disease caused by highly pathogenic Ebolavirus (EBOV), with reported case fatality rates reaching 90%. There have been numerous EBOV outbreaks and epidemics since the first outbreak was reported ...
A systematic evaluation of the language-of-viral-escape model using multiple machine learning frameworks.
Journal of the Royal Society, Interface
Apr 30, 2025
Predicting the evolutionary patterns of emerging and endemic viruses is key for mitigating their spread. In particular, it is critical to rapidly identify mutations with the potential for immune escape or increased disease burden. Knowing which circu...
Machine learning assessment of zoonotic potential in avian influenza viruses using PB2 segment.
BMC genomics
Apr 23, 2025
BACKGROUND: Influenza A virus (IAV) is a major global health threat, causing seasonal epidemics and occasional pandemics. Particularly, Influenza A viruses from avian species pose significant zoonotic threats, with PB2 adaptation serving as a critica...
Genome evolution of Kaposi sarcoma-associated herpesvirus (KSHV).
Journal of virology
Apr 16, 2025
UNLABELLED: Kaposi sarcoma (KS) is the most common cancer in people living with HIV (PLWH), particularly in sub-Saharan Africa (SSA), where Kaposi sarcoma herpesvirus (KSHV or human herpesvirus 8 [HHV-8]) is endemic. In KSHV endemic areas, the overal...
Deep Learning-Based Comparative Prediction and Functional Analysis of Intrinsically Disordered Regions in SARS-CoV-2.
International journal of molecular sciences
Apr 5, 2025
This study explores the role of intrinsically disordered regions (IDRs) in the SARS-CoV-2 proteome and their potential as targets for small-molecule drug discovery. Experimentally validated intrinsic disordered regions from the literature were utiliz...
Cucumber green mottle mosaic virus encodes additional small proteins with specific subcellular localizations and virulence function.
Science China. Life sciences
Apr 1, 2025
The vast majority of known viruses belong to the positive-sense single-stranded RNA (+ssRNA) class. Tobamoviruses are among the most destructive plant viruses and threaten global food security. It is generally accepted that +ssRNA viruses including t...
A Review of In Silico Approaches for Discovering Natural Viral Protein Inhibitors in Aquaculture Disease Control.
Journal of fish diseases
Mar 20, 2025
Viral diseases pose a significant threat to the sustainability of global aquaculture, causing economic losses and compromising food security. Traditional control methods often demonstrate limited effectiveness, highlighting the need for alternative a...
PhageDPO: A machine-learning based computational framework for identifying phage depolymerases.
Computers in biology and medicine
Feb 13, 2025
Bacteriophages (phages) are the most predominant and genetically diverse biological entities on Earth. Phages are viruses that infect bacteria and encode numerous proteins with potential biotechnological application. However, most phage-encoded prote...
Supervised learning approaches for predicting Ebola-Human Protein-Protein interactions.
Gene
Jan 17, 2025
The goal of this research work is to predict protein-protein interactions (PPIs) between the Ebola virus and the host who is at risk of infection. Since there are very limited databases available on the Ebola virus; we have prepared a comprehensive d...
ViroNia: LSTM based proteomics model for precise prediction of HCV.
Computers in biology and medicine
Dec 29, 2024
Classification of viruses carries important implications in terms of understanding their evolution and the designing of interventions. This study introduces ViroNia as a novel LSTM-based system specifically meant for high-accuracy classification of v...
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