AI Medical Compendium

Redesigning miR-34a: structural and chemical advances in the therapeutic development of an miRNA anti-cancer agent.

Biochemical Society transactions Aug 4, 2025

MicroRNAs (miRNAs) represent a promising class of therapeutics due to their ability to down-regulate multiple genes simultaneously. This offers a significant therapeutic advantage in cancer, where heterogeneity often activates different pathways in d... read more

Optimizing FCN for devices with limited resources using quantization and sparsity enhancement.

Scientific reports Aug 4, 2025

This study addresses the optimization of fully convolutional networks (FCNs) for deployment on resource-limited devices in real-time scenarios. While prior research has extensively applied quantization techniques to architectures like VGG-16, there i... read more

Classification of patients with relapsed/refractory large B-cell lymphoma who do not develop early CRS/NE toxicity using ZUMA clinical trial data.

Journal for immunotherapy of cancer Aug 4, 2025

BACKGROUND: We aimed to develop an actionable and feasible prospective clinical model to estimate toxicity risk to assist chimeric antigen receptor (CAR) T-cell therapy providers with the management of patients with relapsed and/or refractory large B... read more

Humans Retrospective Studies Female Aged Adult Lymphoma, Large B-Cell, Diffuse Male Middle Aged Clinical Trials as Topic Immunotherapy, Adoptive Cytokine Release Syndrome

Harnessing the Potential of Carotenoids for Cancer Therapy: An Integrated Machine Learning and MST Based Approach.

Phytotherapy research : PTR Aug 4, 2025

Receptor tyrosine kinases (RTKs) are high-affinity membrane-anchored receptors involved in cellular communication via various ligands and manage numerous biological processes such as cell growth, differentiation, and metabolism. However, dysregulatio... read more

Accurate and Rapid Ranking of Protein-Ligand Binding Affinities Using Density Matrix Fragmentation and Physics-Informed Machine Learning Dispersion Potentials.

Chemphyschem : a European journal of chemical physics and physical chemistry Aug 4, 2025

The generalized many-body expansion for building density matrices (GMBE-DM), truncated at the one-body level and combined with a purification scheme, is applied to rank protein-ligand binding affinities across two cyclin-dependent kinase 2 (CDK2) dat... read more

FIBOS: R and python packages for analyzing protein packing and structure.

Bioinformatics (Oxford, England) Aug 4, 2025

MOTIVATION: Advances in prediction of the 3D structures of most known proteins through machine learning have achieved unprecedented accuracies. However, although these computed models are remarkably good, they still challenge accuracy at the atomic l... read more

Frequent longitudinal blood microsampling and proteome monitoring identify disease markers and enable timely intervention in a mouse model of type 1 diabetes.

Diabetologia Aug 4, 2025

AIMS/HYPOTHESIS: Type 1 diabetes manifests after irreversible beta cell damage, highlighting the crucial need for markers of the presymptomatic phase to enable early and effective interventions. Current efforts to identify molecular markers of diseas... read more

Resilience as a mediator in the relationship between ambidextrous leadership and nurses' positive attitudes towards artificial intelligence.

BMC nursing Aug 4, 2025

BACKGROUND: Leadership plays a pivotal role in adopting new trends within the nursing domain. Yet, the impact of ambidextrous leadership on nurses' positive attitudes towards artificial intelligence is not well understood. Furthermore, the underlying... read more

Combined nomogram for differentiating adrenal pheochromocytoma from large-diameter lipid-poor adenoma using multiphase CT radiomics and clinico-radiological features.

BMC medical imaging Aug 4, 2025

BACKGROUND AND OBJECTIVE: Adrenal incidentalomas (AIs) are predominantly adrenal adenomas (80%), with a smaller proportion (7%) being pheochromocytomas(PHEO). Adenomas are typically non-functional tumors managed through observation or medication, wit... read more

Humans Retrospective Studies Tomography, X-Ray Computed Female Aged Adult Radiomics Male Middle Aged Nomograms Adenoma Diagnosis, Differential Adrenal Gland Neoplasms Pheochromocytoma

Human fall direction recognition in the indoor and outdoor environment using multi self-attention RBnet deep architectures and tree seed optimization.