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Cytokine Release Syndrome

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Machine learning-based cytokine microarray digital immunoassay analysis.

Biosensors & bioelectronics
Serial measurement of a large panel of protein biomarkers near the bedside could provide a promising pathway to transform the critical care of acutely ill patients. However, attaining the combination of high sensitivity and multiplexity with a short ...

Challenging molecular dogmas in human sepsis using mathematical reasoning.

EBioMedicine
Sepsis is defined as a dysregulated host-response to infection, across all ages and pathogens. What defines a dysregulated state remains intensively researched but incompletely understood. Here, we dissect the meaning of this definition and its impor...

PrCRS: a prediction model of severe CRS in CAR-T therapy based on transfer learning.

BMC bioinformatics
BACKGROUND: CAR-T cell therapy represents a novel approach for the treatment of hematologic malignancies and solid tumors. However, its implementation is accompanied by the emergence of potentially life-threatening adverse events known as cytokine re...