Comprehensive analysis of scRNA-seq and bulk RNA-seq data via machine learning and bioinformatics reveals the role of lysine metabolism-related genes in gastric carcinogenesis.

Journal: BMC cancer
PMID: 40205350

Abstract

BACKGROUND: Gastric cancer (GC) is a highly aggressive and heterogeneous cancer with extremely complex biological characteristics. Lysine and its metabolism are closely related to human cancer, but little is known about how lysine metabolism-related genes contribute to gastric carcinogenesis.

Authors

  • Yongfu Shao
    Department of Gastroenterology, the First Affiliated Hospital of Ningbo University, Ningbo, 315020, China.
  • Chujia Chen
    Health Science Center, Ningbo University, Ningbo, 315211, China.
  • Xuan Yu
    School of Computer Engineering and Science, Shanghai University, Shanghai, China.
  • Jianing Yan
    The Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China.
  • Junming Guo
    Health Science Center, Ningbo University, Ningbo, 315211, China. guojunming@nbu.edu.cn.
  • Guoliang Ye
    Department of Gastroenterology, Affiliated Hospital, Medical School, Ningbo University, Ningbo, China.

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